The Value of Blood Oxygenation Level-Dependent (BOLD) MR Imaging in Differentiation of Renal Solid Mass and Grading of Renal Cell Carcinoma (RCC): Analysis Based on the Largest Cross-Sectional Area versus the Entire Whole Tumour
| Autor: | Wan-qiu Zhu, Jianrong Xu, Qing Lu, Guangyu Wu, Jin Zhang, Shiteng Suo |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Blood oxygenation level dependent lcsh:Medicine Kidney urologic and male genital diseases Diagnosis Differential Hemoglobins Tumor grade Renal cell carcinoma Neoplasms medicine Humans lcsh:Science Carcinoma Renal Cell neoplasms Grading (tumors) Aged Aged 80 and over Observer Variation Multidisciplinary medicine.diagnostic_test business.industry lcsh:R Magnetic resonance imaging Solid mass Middle Aged medicine.disease Mr imaging Kidney Neoplasms female genital diseases and pregnancy complications Oxygen Diffusion Magnetic Resonance Imaging ROC Curve lcsh:Q Female Radiology Neoplasm Grading business Research Article |
| Zdroj: | PLoS ONE PLoS ONE, Vol 10, Iss 4, p e0123431 (2015) |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0123431 |
| Popis: | OBJECTIVES:To study the value of assessing renal masses using different methods in parameter approaches and to determine whether BOLD MRI is helpful in differentiating RCC from benign renal masses, differentiating clear-cell RCC from renal masses other than clear-cell RCC and determining the tumour grade. METHODS:Ninety-five patients with 139 renal masses (93 malignant and 46 benign) who underwent abdominal BOLD MRI were enrolled. R2* values were derived from the largest cross-section (R2*largest) and from the whole tumour (R2*whole). Intra-observer and inter-observer agreements were analysed based on two measurements by the same observer and the first measurement from each observer, respectively, and these agreements are reported with intra-class correlation coefficients and 95% confidence intervals. The diagnostic value of the R2* value in the evaluation was assessed with receiver-operating characteristic analysis. RESULTS:The intra-observer agreement was very good for R2*largest and R2*whole (all > 0.8). The inter-observer agreement of R2*whole (0.75, 95% confidence interval: 0.69~0.79) was good and was significantly improved compared with the R2*largest (0.61, 95% confidence interval: 0.52~0.68), as there was no overlap in the 95% confidence interval of the intra-class correlation coefficients. The diagnostic value in differentiating renal cell carcinoma from benign lesions with R2*whole (AUC=0.79/0.78[observer1/observer2]) and R2*largest (AUC=0.75[observer1]) was good and significantly higher (p=0.01 for R2*largest[observer2] vs R2*whole[observer2], p 0.7) and were not significantly different (p=0.89/0.93 for R2*largest vs R2*whole[observer1/observer2], 0.96 for R2*whole[observer1] vs R2*largest[observer2] and 0.96 for R2*whole [observer2] vs R2*largest[observer1]). CONCLUSIONS:BOLD MRI could provide a feasible parameter for differentiating renal cell carcinoma from benign renal masses and for predicting clear-cell renal cell carcinoma grading. Compared with the largest cross-section, assessing the whole tumour provides better inter-observer agreement in parameter measurement for differentiating renal cell carcinoma from benign renal masses. |
| Databáze: | OpenAIRE |
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