Combined treatment using peripheral nerve graft and FGF-1: Changes to the glial environment and differential macrophage reaction in a complete transected spinal cord
| Autor: | Huai Sheng Kuo, Henrich Cheng, Jau Ching Wu, May J. Tsai, Wen Cheng Huang, Chu Hsun Cheng, Meng-Jen Lee, Ching Jung Chen, Wen Chi Chang, Ming Chao Huang |
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| Rok vydání: | 2008 |
| Předmět: |
Pathology
medicine.medical_specialty Central nervous system Down-Regulation Biology Fibroblast growth factor Rats Sprague-Dawley White matter Glial Fibrillary Acidic Protein Neural Pathways medicine Animals Macrophage Gliosis Peripheral Nerves Spinal Cord Injuries Macrophages General Neuroscience Graft Survival Anatomy equipment and supplies Spinal cord Nerve Regeneration Rats Disease Models Animal Treatment Outcome medicine.anatomical_structure nervous system Astrocytes Tissue Transplantation Fibroblast Growth Factor 1 Neuroglia Female Proteoglycans medicine.symptom Wallerian Degeneration Biomarkers Astrocyte |
| Zdroj: | Neuroscience Letters. 433:163-169 |
| ISSN: | 0304-3940 |
| Popis: | We used a complete spinal cord transection model in which the T8 spinal segment was removed to study the effect of combined treatment of peripheral nerve graft and application of FGF-1 on the glial environment. The combined treatment resulted in reduced astrocytic glial scarring, reactive macrophage gliosis, and inhibitory proteoglycan in the back-degenerated white matter tract. While the macrophage activities in the back-degenerative tract were down-regulated, those in the grafted peripheral nerves and in the distal Wallerian degenerative tracts were not. We concluded that the combined treatment changed the glial environment in the back-degenerative tract, and differentially regulated the macrophage activities in the system, in favor of CNS regeneration. |
| Databáze: | OpenAIRE |
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