Liver stiffness assessed by shear-wave elastography declines in parallel with immunoregulatory proteins in patients with chronic HCV infection during DAA therapy
| Autor: | Ernst-Michael Jung, K Pollinger, Jens M. Werner, Jonathan Grimm, G Peschel, Christa Buechler, Kilian Weigand, Mathias Müller, S Kammerer, M Gunckel, E Aschenbrenner, Michael Haimerl |
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| Rok vydání: | 2021 |
| Předmět: |
Liver Cirrhosis
medicine.medical_specialty Physiology Inflammation Gastroenterology Antiviral Agents 03 medical and health sciences 0302 clinical medicine Interferon Fibrosis Liver stiffness Physiology (medical) Internal medicine medicine Humans In patient biology business.industry Interleukin Hematology Hepatitis C Chronic medicine.disease Hepatitis C Ferritin Liver 030220 oncology & carcinogenesis biology.protein Elasticity Imaging Techniques 030211 gastroenterology & hepatology Tumor necrosis factor alpha medicine.symptom Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Clinical hemorheology and microcirculation. 79(4) |
| ISSN: | 1875-8622 |
| Popis: | BACKGROUND: A rapid decline of liver stiffness (LS) was detected by non-invasive methods in patients with chronic hepatitis C (HCV) infection during treatment with direct-acting antivirals (DAA). OBJECTIVE: To investigate the influence of inflammation on LS. METHODS: We prospectively examined LS by sonographic shear-wave elastography in 217 patients during DAA therapy from treatment initiation (BL) to 12 weeks after end of therapy (SVR12). Demographic data, laboratory findings and serum levels of cytokines were determined. RESULTS: Values of LS decreased from 1.86 m/s to 1.68 m/s (p = 0.01) which was most pronounced in patients who had F4 fibrosis at BL (3.27 m/s to 2.37 m/s; p |
| Databáze: | OpenAIRE |
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