A High Burden of Asymptomatic Gastrointestinal Infections in Traditional Communities in Papua New Guinea
| Autor: | Paul F. Horwood, Kazumi Natsuhara, Tobias Maure, Emma S. McBryde, Kevin W. Soli, Jun Baba, Jo-ann Larkins, Andrew R. Greenhill, Eriko Tomitsuka, Kiyoshi Tadokoro, Yuichi I. Naito, Masahiro Umezaki, Peter Siba, Katsura Igai, Shingo Odani, Ayako Morita, William Pomat |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Diarrhea 0301 basic medicine Veterinary medicine Gastrointestinal Diseases Cross-sectional study 030106 microbiology Population Biology Asymptomatic Gastrointestinal infections Enteropathogenic Escherichia coli Feces Papua New Guinea 03 medical and health sciences 0302 clinical medicine Virology parasitic diseases medicine Enterotoxigenic Escherichia coli Humans 030212 general & internal medicine education Asymptomatic Infections Pathogen education.field_of_study Helicobacter pylori Norovirus Gastrointestinal Microbiome New guinea Campylobacter Articles Cross-Sectional Studies Infectious Diseases Carriage Parasitology Shigella medicine.symptom |
| Zdroj: | The American Journal of Tropical Medicine and Hygiene |
| ISSN: | 1476-1645 0002-9637 |
| Popis: | Stool samples were collected from 148 healthy adults living a traditional subsistence lifestyle in Papua New Guinea and screened for enteric pathogens using real-time RT-PCR/PCR assays. Enteric pathogens were detected in a high proportion (41%) of individuals. Clear differences were observed in the detection of pathogens between highland and lowland communities. In particular, there was a marked difference in detection rates of norovirus GII (20% and 0%, respectively) and Shigella sp. (15% and 0%, respectively). Analysis of the relationship between enteric pathogen carriage and microbial community composition of participants, using box plots to compare specific normal flora population numbers, did not suggest that gut microbial composition was directly associated with pathogen carriage. This study suggests that enteric pathogens are common in healthy individuals in Papua New Guinean highland communities, presumably acting as a reservoir of infection and thus contributing to a high burden of gastrointestinal illnesses. |
| Databáze: | OpenAIRE |
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