Antibiotic susceptibility of 65 isolates of Burkholderia pseudomallei and Burkholderia mallei to 35 antimicrobial agents
| Autor: | François M. Thibault, Eric Hernandez, Dominique R. Vidal, J.-D. Cavallo, Monique Girardet |
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| Rok vydání: | 2004 |
| Předmět: |
Microbiology (medical)
Imipenem Burkholderia pseudomallei Ceftazidime Microbial Sensitivity Tests Biology Tazobactam Burkholderia mallei Microbiology Agar dilution Biological Warfare Drug Resistance Bacterial polycyclic compounds medicine Animals Humans Pharmacology (medical) Horses Antibacterial agent Pharmacology biochemical phenomena metabolism and nutrition bacterial infections and mycoses biology.organism_classification Virology Anti-Bacterial Agents Rats Infectious Diseases Melioidosis Glanders bacteria Horse Diseases medicine.drug Piperacillin |
| Zdroj: | The Journal of antimicrobial chemotherapy. 54(6) |
| ISSN: | 0305-7453 |
| Popis: | Objectives Fifty isolates of Burkholderia pseudomallei and 15 isolates of Burkholderia mallei were tested for their susceptibilities to 35 antimicrobial agents, including agents not previously tested against these bacteria. Methods MICs were determined by agar dilution in Mueller-Hinton medium. Results Among the antibiotics tested, lower MICs were obtained with imipenem, ceftazidime, piperacillin, piperacillin/tazobactam, doxycycline and minocycline. Fluoroquinolones and aminoglycosides had poor activities. A single clinical isolate of B. pseudomallei was resistant to ceftazidime, co-amoxiclav and doxycycline but remained susceptible to imipenem. Conclusions Although B. mallei MICs are often lower, the overall results underline the importance of resistance in both species. The susceptibilities measured are consistent with the current recommendations for the treatment of B. pseudomallei and B. mallei infections. |
| Databáze: | OpenAIRE |
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