Pure photosensitizer-driven nanoassembly with core-matched PEGylation for imaging-guided photodynamic therapy
| Autor: | Cong Luo, Bingjun Sun, Zhiqiang Kong, Xuanbo Zhang, Yuequan Wang, Jin Sun, Zhonggui He, Qin Chen, Shenwu Zhang, Han Yu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
SDS
sodium dodecyl sulfate CRE creatinine medicine.medical_treatment PS photosensitizer nano-DDS nanoparticulate drug delivery systems Nanoparticle Photodynamic therapy AST aspartate aminotransferase RM1-950 Pyropheophorbide a Imaging-guided Systemic circulation Nanoassembly Hydrophobic effect 03 medical and health sciences NaCl sodium chloride ROS reactive oxygen species Pure photosensitizer 0302 clinical medicine FBS fetal bovine serum ALT alanine aminotransferase Amphiphile PEG ratio medicine DCFH-DA 2′ 7′-dichlorofluorescein diacetate Photosensitizer General Pharmacology Toxicology and Pharmaceutics SOSG Singlet Oxygen Sensor Green Reagent NPs nanoparticles 030304 developmental biology 0303 health sciences Chemistry DDS drug delivery system PDANs pure drug-assembled nanomedicines Self-assembly respiratory system ACQ aggregation caused quenching BUN blood urine nitrogen PDT photodynamic therapy PBS phosphate buffer solution Pure drug-assembled nanomedicines 030220 oncology & carcinogenesis PEGylation Biophysics Original Article PPa pyropheophorbide a Therapeutics. Pharmacology Core-matched |
| Zdroj: | Acta Pharmaceutica Sinica B, Vol 11, Iss 11, Pp 3636-3647 (2021) Acta Pharmaceutica Sinica. B |
| ISSN: | 2211-3835 |
| DOI: | 10.1016/j.apsb.2021.04.005 |
| Popis: | Pure drug-assembled nanomedicines (PDANs) are currently under intensive investigation as promising nanoplatforms for cancer therapy. However, poor colloidal stability and less tumor-homing ability remain critical unresolved problems that impede their clinical translation. Herein, we report a core-matched nanoassembly of pyropheophorbide a (PPa) for photodynamic therapy (PDT). Pure PPa molecules are found to self-assemble into nanoparticles (NPs), and an amphiphilic PEG polymer (PPa-PEG2K) is utilized to achieve core-matched PEGylating modification via the π‒π stacking effect and hydrophobic interaction between the PPa core and the PPa-PEG2K shell. Compared to PCL-PEG2K with similar molecular weight, PPa-PEG2K significantly increases the stability, prolongs the systemic circulation and improves the tumor-homing ability and ROS generation efficiency of PPa-nanoassembly. As a result, PPa/PPa-PEG2K NPs exert potent antitumor activity in a 4T1 breast tumor-bearing BALB/c mouse xenograft model. Together, such a core-matched nanoassembly of pure photosensitizer provides a new strategy for the development of imaging-guided theragnostic nanomedicines. Graphical abstract Pyropheophorbide a (PPa)-driven nanoassembly was formed by the core-matched modification of PPa-PEG2K. Afterwards, PPa/PPa-PEG2K NPs are endocytosed by tumor cells to exert effective photodynamic under laser irradiation.Image 1 |
| Databáze: | OpenAIRE |
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