Oxidative Stress in Chronic Hepatitis C: The Effect of Interferon Therapy and Correlation with Pathological Features
| Autor: | Afonso Fernandes, Maria Adília Costa, Joao Freitas, Fátima Serejo, Ingrid Emerit, Paulo Filipe, Miguel Carneiro de Moura |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Interferon therapy Interferon alpha-2 medicine.disease_cause Antiviral Agents Chronic hepatitis Interferon Malondialdehyde medicine Humans Aspartate Aminotransferases lcsh:RC799-869 Pathological Aged business.industry Biopsy Needle Gastroenterology Interferon-alpha Alanine Transaminase Chromosome Breakage Histology General Medicine Hepatitis C Hepatitis C Chronic Middle Aged medicine.disease Peptide Fragments Recombinant Proteins Oxidative Stress Liver Immunology Female lcsh:Diseases of the digestive system. Gastroenterology business Procollagen Oxidative stress medicine.drug |
| Zdroj: | Canadian Journal of Gastroenterology, Vol 17, Iss 11, Pp 644-650 (2003) |
| ISSN: | 0835-7900 |
| DOI: | 10.1155/2003/710693 |
| Popis: | AIMS: To evaluate the oxidative stress parameters before, during and after interferon treatment.PATIENTS/METHODS: Twenty patients were treated with interferon α2b 5 MU, three times a week, subcutaneously, for 12 months. Liver biopsy was performed six months before treatment and at the six month follow-up. Chromosomal breakage studies were evaluated by the adjusted clastogenic score (ACS, normal value [nv] 1.1±2.4%). Plasma malondialdehyde (MDA) was measured according to the Yagi method (nv 6.6±1.4 nmol/mL) and total thiols using the Ellman’s reagent (DTNB) (nv 9.8±1.3 µmol/g protein). A serum marker of fibrogenesis, the amino-terminal propeptide of Procollagen type III (PIIIP), was quantified by radioimmunoassay (nv 0.37±0.18 U/L).RESULTS: Compared with reference samples, the plasma of patients before treatment showed an increase of ACS (9.2±3.2%, PCONCLUSIONS: The present study confirmed the presence of oxidative stress in chronic hepatitis C patients. Interferon promotes a long term inhibition of oxidative stress with concomitant improvement of activity and fibrosis. In the management of chronic hepatitis C, adjuvant therapy with antioxidants could be useful. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|