Circulating monocyte oxidative activity is increased in patients with type 2 diabetes and erectile dysfunction
| Autor: | Emmanuele A. Jannini, Claudio Tiberti, Barbara Buchetti, Paolo Sgrò, Alessandra Gatti, Mara Fallarino, Elisabetta Mandosi, Loredana Gandini, Andrea Lenzi, Rosalba Cipriani, Susanna Morano, Luisa Lenti |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Urology impotence free radicals Type 2 diabetes medicine.disease_cause Monocytes Diabetes Complications chemistry.chemical_compound Erectile Dysfunction Diabetes mellitus Internal medicine Plasminogen Activator Inhibitor 1 Medicine Humans Endothelin-1 business.industry Middle Aged medicine.disease Intercellular Adhesion Molecule-1 Endocrinology Blood pressure Erectile dysfunction chemistry type 2 Diabetes Mellitus Type 2 Low-density lipoprotein diabetes mellitus monocytes Endothelium Vascular business Reactive Oxygen Species Plasminogen activator Body mass index Oxidative stress |
| Zdroj: | The Journal of urology. 177(2) |
| ISSN: | 0022-5347 |
| Popis: | We investigated the relationship between oxidative stress and diabetic erectile dysfunction.A total of 23 patients with a mean +/- SD age of 56.7 +/- 5.6 years, a history of type 2 diabetes for 10.0 +/- 8.3 years and erectile dysfunction, as tested by the International Index of Erectile Function questionnaire, but without vascular and neurological complications, and 15 age matched patients with diabetes without erectile dysfunction were recruited. Circulating monocyte oxidative activity by cytofluorometry, and endothelin-1, intercellular adhesion molecule-1, plasminogen activator inhibitor-1 by enzyme linked immunosorbent assay were evaluated in all patients in the study.Monocyte free radical production, and total and low density lipoprotein cholesterol were higher in patients with than in those without erectile dysfunction (p0.03,0.02 and0.05, respectively). In all patients the International Index of Erectile Function score inversely correlated with low density lipoprotein (p0.05), while in patients with erectile dysfunction it negatively correlated with age (p0.03), body mass index (p0.02), endothelin-1 (p0.02) and intercellular adhesion molecule-1 (p0.05). Endothelin-1, intercellular adhesion molecule-1 and plasminogen activator inhibitor-1 were not different in patients with diabetes with and without erectile dysfunction.In men with type 2 diabetes who have erectile dysfunction but are asymptomatic for cardiovascular disease oxidative activation of monocytes is increased and it is related to other risk factors of endothelial dysfunction. |
| Databáze: | OpenAIRE |
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