New concepts in organ preservation
| Autor: | T Carrel, Paul Mohacsi, Thomas Laumonier, U E Nydegger |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Calcium Channel Blockers/pharmacology
Organ Preservation Solutions/pharmacology Organ Preservation Solutions Immunology Trimetazidine Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology Apoptosis Acetylcysteine/pharmacology Bioinformatics Long term survival Animals Humans Immunology and Allergy Medicine Organ donation Fluorocarbons Transplantation business.industry Biochemical stress Apoptosis/drug effects Fluorocarbons/pharmacology Temperature Membrane Proteins Organ Preservation Trimetazidine/pharmacology Calcium Channel Blockers Acetylcysteine Clinical Practice Heme Oxygenase (Decyclizing)/physiology Heme Oxygenase (Decyclizing) Hydroxymethylglutaryl-CoA Reductase Inhibitors business Heme Oxygenase-1 |
| Zdroj: | Transplant Immunology, Vol. 9, No 2-4 (2002) pp. 215-25 |
| ISSN: | 0966-3274 |
| DOI: | 10.1016/s0966-3274(02)00049-7 |
| Popis: | Organ preservation between donor and recipient is an important link in a chain that ultimately should lead to long term survival of the recipient thanks to a well-preserved, functionally intact organ. The period of organ ischaemia outside the body is subject to a number of biochemical stress factors which become known in more detail as knowledge on biochemical and immunological mechanisms improves. Efficacy of preservation fluids hence reduction of ischaemia injury may become enhanced by such additives as ion channel blockers, enzyme inhibitors, haeme oxygenase modulators, endothelin-l-inhibitors, quenchers of free radicals and anti-apoptotic agents. Many of these compounds, albeit of great theoretical interest, have not (yet?) made their way into clinical practice. This contribution is a survey of some promising agents, concentration and physicochemical interactions of which are analysed in some detail. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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