Significance of descriptive symptoms and signs and clinical parameters as predictors of neuropathic cancer pain
| Autor: | Hyo Jung Kim, Ha Yeong Gil, Hwan Jung Yun, Sang Won Shin, Jung Han Kim, Sun Kyung Baek, Byoung Yong Shim, Su-Jin Koh, Seok Yun Kang, Sun Jin Sym, Hye Sook Han, Sang Byung Bae |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Multivariate analysis medicine.medical_treatment Cancer Treatment Informed consent Neoplasms Surveys and Questionnaires Medicine and Health Sciences Prevalence Pain Measurement Multidisciplinary Pharmaceutics Age Factors Obstetrics and Gynecology Cancer Pain Middle Aged Oncology Neuropathic pain Medicine Female Research Article Clinical Oncology medicine.medical_specialty Visual analogue scale Science Pain Surgical and Invasive Medical Procedures Cancer Chemotherapy Signs and Symptoms Drug Therapy Internal medicine medicine Chemotherapy Humans Neuropathic Pain Aged business.industry Gynecologic Cancers Cancers and Neoplasms Cancer medicine.disease Women's Health Neuralgia Observational study Clinical Medicine Cancer pain business |
| Zdroj: | PLoS ONE, Vol 16, Iss 8, p e0252781 (2021) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Purpose Evaluation of symptoms and signs for the management of neuropathic cancer pain (NCP) is challenging. This study aimed to identify clinical predictors of NCP and symptoms and signs most relevant of those in Korean patients. Methods This nationwide, descriptive, cross-sectional, multicenter, observational study included 2,003 cancer patients aged ≥20 years who reported a visual analog scale (VAS) score ≥1 for pain and provided informed consent for participation. The Douleur Neuropathic (DN4) questionnaire (score ≥4) was used to determine symptoms and signs as well as the presence of NCP. Results The prevalence of NCP was associated with age 6 months (OR, 1.57; 95% CI, 1.232–2.012), stage IV cancer (OR, 0.75; 95% CI, 0.593–0.955), history of chemotherapy (OR, 1.74; 95% CI, 1.225–2.472), and moderate-to-severe cancer pain (OR, 2.05; 95% CI, 1.671–2.524) after multivariate analysis. The most common descriptive symptoms of NCP were tingling, electric shock, and pins and needles. For NCP patients in the presence or absence of the clinical predictors, pins and needles (p = 0.001) and painful cold (p Conclusion Age 6 months, stage IV cancer, history of chemotherapy, and moderate-to-severe cancer pain, were identified as predictors of NCP. Some symptoms and signs of NCP were associated with these predictors. Further studies are warranted on the pathogenesis and management of NCP with respect to the symptoms and signs, and factors associated with pain severity in Korean patients. |
| Databáze: | OpenAIRE |
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