Chemical constituents from plant endophytic fungus Alternaria alternata
| Autor: | Feng-Qing Xu, Yang Yu, Dai-Yin Peng, Gang Wang, Jin-Song Liu, Guo-Kai Wang, Zong-Hui Ma, Ju-Tao Wang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Paeonia lactiflora
biology 010405 organic chemistry Chemistry Organic Chemistry Plant Science Endophytic fungus biology.organism_classification Alternaria 01 natural sciences Biochemistry Alternaria alternata 0104 chemical sciences Analytical Chemistry 010404 medicinal & biomolecular chemistry Chemical constituents Botany |
| DOI: | 10.6084/m9.figshare.8870498 |
| Popis: | Five new natural compounds (1–5) along with four known ones, involving dibenzo-α-pyrone derivatives, a benzo-γ-pyrone derivative and an amide-type compound were obtained from Alternaria alternata, an endophyte isolated from Paeonia lactiflora. The structures of these isolates were elucidated by intensive analysis of spectroscopic data including NMR, HRMS (ESI and EI), UV and IR spectra. Compounds (1–4) were evaluated for their cytotoxicities against five selected human tumourtumour cell lines (A-549, MDA-MB-231, MCF-7, KB and KB-VIN), and compound 3 exhibited activities against MDA-MB-231and MCF-7 with IC50 values of 20.1 μM and 32.2 μM. |
| Databáze: | OpenAIRE |
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