Aortic valve calcification among elderly males from the general population, associated echocardiographic findings, and clinical implications
| Autor: | Lida Khurrami, Flemming Hald Steffensen, Jes S. Lindholt, Jacob E. Møller, Jess Lambrechtsen, Grazina Urbonaviciene, Jordi Sancez Dahl, Lasse M Obel, Maise Hoeigaard Fredgart, Axel Cosmus Pyndt Diederichsen |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Population aortic valve calcification cardiac CT Severity of Illness Index Muscle hypertrophy Aortic valve replacement Internal medicine Humans Medicine Radiology Nuclear Medicine and imaging education Aged education.field_of_study business.industry Screening Trial Area under the curve Calcinosis aortic stenosis Aortic Valve Stenosis General Medicine medicine.disease Aortic valve area Echocardiography Aortic Valve Aortic valve stenosis Cardiology epidemiology Aortic valve calcification Cardiology and Cardiovascular Medicine business |
| Zdroj: | Khurrami, L, Møller, J E, Lindholt, J S, Dahl, J S, Fredgart, M H, Obel, L M, Steffensen, F H, Urbonaviciene, G, Lambrechtsen, J & Diederichsen, A C P 2022, ' Aortic valve calcification among elderly males from the general population, associated echocardiographic findings, and clinical implications ', European Heart Journal Cardiovascular Imaging, vol. 23, no. 2, pp. 177-184 . https://doi.org/10.1093/ehjci/jeab182 |
| ISSN: | 2047-2412 2047-2404 |
| DOI: | 10.1093/ehjci/jeab182 |
| Popis: | Aims Aortic valve calcification (AVC) detected by non-contrast computed tomography (NCCT) associates with morbidity and mortality in patients with aortic valve stenosis. However, the importance of AVC in the general population is sparsely evaluated. We intend to describe the associations between AVC score on NCCT and echocardiographic findings as left atrial (LA) dilatation, left ventricular (LV) hypertrophy, aortic valve area (AVA), peak velocity, mean gradient, and aortic valve replacement (AVR) in a population with AVC scores ≥300 AU. Methods and results Of 10 471 males aged 65–74 years from the Danish Cardiovascular Screening trial (DANCAVAS), participants with AVC score ≥300 AU were invited for transthoracic echocardiography and 828 (77%) of 1075 accepted the invitation. AVC scores were categorized (300–599, 600–799, 800–1199, and ≥1200 AU). AVR was obtained from registries. AVC was significantly associated with a steady increase in LA dilation (10.5%, 16.3%, 15.8%, 19.6%, P = 0.031), LV hypertrophy (3.9%, 6.6%, 8.9%, 10.1%, P = 0.021), peak velocity (1.7, 1.9, 2.1, 2.8 m/s, P = 0001), mean gradient (6, 8, 11, 19 mmHg, P = 0.0001), and a decrease in AVA (2.0, 1.9, 1.7, 1.3 cm2, P = 0.0001). The area under the curve was 0.79, 0.93, and 0.92 for AVA ≤1.5 cm2, peak velocity ≥3.0 m/s, and mean gradient ≥20 mmHg, respectively, and the associated optimal AVC score thresholds were 734, 1081, and 1019 AU. AVC > 1200 AU was associated with AVR (P Conclusion Among males from the background population, increasing AVC scores were associated with LA dilatation, LV hypertrophy, AVA, peak aortic velocity, mean aortic gradient, and AVR. |
| Databáze: | OpenAIRE |
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