Vulnerability to psychogenic non-epileptic seizures is linked to low neuropeptide Y levels

Autor: Paul J. Zak, Michael Winterdahl, Alessandro Miani, Antonia Ciovica, Charlotte Ulrikka Rask, Lori Uber-Zak, Moana J. H. Vercoe
Rok vydání: 2017
Předmět:
PNES
Hydrocortisone
Physiology
Oxytocin
Behavioral Neuroscience
stress
0302 clinical medicine
Quality of life
Neuropeptide Y
Testosterone
Progesterone
Estradiol
Electroencephalography
Resilience
Psychological
Neuropeptide Y receptor
humanities
negative life events
Psychiatry and Mental health
Neuropsychology and Physiological Psychology
Abandonment (emotional)
Female
Disease Susceptibility
Psychology
Adult
medicine.medical_specialty
NPY
cortisol
03 medical and health sciences
Young Adult
Adrenocorticotropic Hormone
Seizures
Psychogenic non-epileptic seizures
mental disorders
medicine
Psychogenic disease
Humans
Psychiatry
Conversion disorder
Endocrine and Autonomic Systems
Stressor
Sex Offenses
medicine.disease
030227 psychiatry
ACTH
Prolactin
Sexual abuse
Conversion Disorder
Case-Control Studies
Quality of Life
030217 neurology & neurosurgery
Stress
Psychological
Zdroj: Winterdahl, M, Miani, A, Vercoe, M, Ciovica, A, Uber-Zak, L, Rask, C U & Zak, P 2017, ' Vulnerability to psychogenic non-epileptic seizures is linked to low neuropeptide Y levels ', Stress: The International Journal on the Biology of Stress, pp. 1-9 . https://doi.org/10.1080/10253890.2017.1378638
ISSN: 1607-8888
DOI: 10.1080/10253890.2017.1378638
Popis: Psychogenic non-epileptic seizures (PNES) is a conversion disorder that reflects underlying psychological distress. Female patients with PNES often present with a history of prolonged stressors, especially sexual abuse. In the current study, we studied the relationship between neuropeptide Y (NPY) and PNES symptoms in women with a history of sexual abuse. NPY has been associated with resilience to stress and we hypothesized that low levels would increase the extent and severity of PNES symptoms in this patient population. Serum levels of NPY, and related hormones were measured in fifteen female PNES patients and sixty female controls. PNES patients reported more severe abuse histories, feeling of abandonment, and decreased perception of quality of life than controls. Importantly, they also had lower NPY levels. Our analysis indicates that low levels of NPY in PNES may confer greater vulnerability to exhibit seizure-like symptoms and lower quality of life.
Databáze: OpenAIRE
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