Effects of estrogen and estrogen-progesteron on serum nitric oxide metabolite concentrations in post-menopausal women
| Autor: | K. Tupikowski, Grazyna Bednarek-Tupikowska, U. Tworowska-Bardzińska |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
Apolipoprotein B medicine.drug_class Endocrinology Diabetes and Metabolism Metabolite Lipoproteins Medroxyprogesterone Acetate Administration Cutaneous Nitric Oxide Nitric oxide chemistry.chemical_compound Endocrinology Internal medicine Medicine Medroxyprogesterone acetate Humans biology Estradiol Cholesterol business.industry Estrogen Replacement Therapy Middle Aged medicine.disease Menopause Postmenopause chemistry Premenopause Estrogen biology.protein Hormonal therapy Female Nitrogen Oxides business medicine.drug |
| Zdroj: | Journal of endocrinological investigation. 31(10) |
| ISSN: | 1720-8386 |
| Popis: | Estrogens have some anti-atherosclerotic prop- erties and they influence nitric oxide (NO) production. The aim of this study was to determine NOx levels in post-meno- pausal women and the effect of estrogen/estrogen-proges- teron therapy (ET/EPT) on plasma NO levels. Eighty post- menopausal women (M1) comprising 26 with surgically in- duced menopause (ET1), mean age 50.9±2.9 yr, and 54 with physiological menopause (EPT1), mean age 50.5±3.0 yr, were studied. Forty healthy pre-menopausal women, mean age 48.3±2.3 yr were the controls (C). The post-menopausal wom- en were treated for 4 months: group ET1 with ET and group EPT1 with EPT. Serum estradiol (E2), FSH, NOx and lipid pro- file before and after therapy were measured. NOx levels were lower in group M1 than in group C (8.75±1.57 vs 10.27±2.62, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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