A stitch in time saves nine: timely use of N-acetyl cysteine (NAC) for chemotherapy-induced veno-occlusive disease (VOD)-is it a cost-effective alternative?

Autor:	Harish Varma Tandra, Thirumala Rupakumar, Kalasekhar Vijayasekharan, Prasanth V R, Guruprasad C S, Priya Kumari T
Rok vydání:	2022
Předmět:	Polydeoxyribonucleotides Oncology Cost-Benefit Analysis Hepatic Veno-Occlusive Disease Hematopoietic Stem Cell Transplantation Humans Antineoplastic Agents Vascular Diseases Child Acetylcysteine
Zdroj:	Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. 30(11)
ISSN:	1433-7339
Popis:	Chemotherapy-induced veno-occlusive disease (VOD) is a rare liver dysfunction seen among pediatric cancer patients which could lead to severe morbidity and mortality. Defibrotide is the commonly used antidote in the management of both stem cell transplant and chemotherapy-associated VOD along with liver supportive measures. Defibrotide is costly and generally not accessible to majority of patients treated at resource poor settings. In this report, we describe the successful management of chemotherapy-induced VOD with timely administration of N-acetyl cysteine.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b8e92b45256aebb2a99e95ad850aba7 https://pubmed.ncbi.nlm.nih.gov/35963952 Zobrazit plný text záznamu Full text from SpringerLink