Going beyond the chest X‐ray: Investigating laterality defects in primary ciliary dyskinesia

Autor:	Wallace B. Wee, Kimberley R. Kaspy, Michael G. Sawras, Michael R. Knowles, Maimoona A. Zariwala, Margaret W. Leigh, Sharon D. Dell, Adam J. Shapiro
Rok vydání:	2022
Předmět:	Adult Pulmonary and Respiratory Medicine Canada Kartagener Syndrome X-Rays Respiration Disorders Situs Inversus Article Radiography Pediatrics Perinatology and Child Health otorhinolaryngologic diseases Humans Child Ciliary Motility Disorders Retrospective Studies
Zdroj:	Pediatr Pulmonol
ISSN:	1099-0496 8755-6863
Popis:	BACKGROUND: Organ laterality defects in primary ciliary dyskinesia (PCD) are common, ranging from complete mirror image organ arrangement, situs inversus totalis (SIT), to situs ambiguus (SA), which falls along the spectrum of situs solitus (SS) and SIT. Targeted investigations for organ laterality defects are not universally recommended in PCD consensus statements. Without investigations beyond chest radiography (CXR), clinically significant defects may go undetected leading to increased morbidity. We hypothesize that clinically significant SA defects remain undetected on CXR and targeted investigations are needed to detect various laterality defects associated with morbidity. METHODS: This retrospective study collected data from PCD clinics at two Canadian children’s hospitals from 2012 to 2020. Participants
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b8e661e62acedc1b8497afce7211e8a https://doi.org/10.1002/ppul.25853 Zobrazit plný text záznamu Plný text