A biochemical study of tardive dyskinesia in young male patients
| Autor: | Steven G. Potkin, Steven Zalcman, C.David Wise, Lynn E. DeLisi, Richard Jed Wyatt, T.Peter Bridge, Bruce H. Phelps, Dilip V. Jeste, Jack E. Rosenblatt |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Adult
Blood Platelets Male Dyskinesia Drug-Induced Serotonin medicine.medical_specialty Monoamine oxidase Population Dopamine beta-Hydroxylase Tardive dyskinesia Internal medicine medicine Humans Platelet monoamine oxidase education Monoamine Oxidase Biological Psychiatry Young male Whole blood education.field_of_study business.industry Middle Aged medicine.disease Psychiatry and Mental health Endocrinology Dyskinesia Schizophrenia medicine.symptom business Antipsychotic Agents |
| Zdroj: | Psychiatry Research. 4:327-331 |
| ISSN: | 0165-1781 |
| DOI: | 10.1016/0165-1781(81)90034-2 |
| Popis: | Based on specific criteria, tardive dyskinesia was diagnosed in 6 out of 29 young schizophrenic male inpatients. We compared several biochemical parameters in these six dyskinesia patients with those in six matched controls. The patients with dyskinesia had significantly lower platelet monoamine oxidase activity and significantly higher plasma dopamine-β-hydroxylase activity as compared with the controls, thus confirming our previous findings in a population of elderly female inpatients. The dyskinetic and nondyskinetic groups did not differ from each other in mean whole blood serotonin concentration and mean serum neuroleptic concentration as measured with a radioreceptor binding assay. Possible significance of our results is discussed. |
| Databáze: | OpenAIRE |
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