Xidimmunodeficiency imparts increased parasite clearance and resistance to pathology in experimental Chagas' disease
| Autor: | Antonio Coutinho, M. Hontebeyrie-Joskowicz, Paola Minoprio, S. Spinella |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Chagas Cardiomyopathy
Male Chagas disease Pathology medicine.medical_specialty Trypanosoma cruzi medicine.medical_treatment Lymphocyte Immunology Antibodies Protozoan chemical and pharmacologic phenomena Parasitemia Lymphocyte Activation Autoimmune Diseases Mice medicine Animals Immunology and Allergy Chagas Disease Immunodeficiency B cell B-Lymphocytes Mice Inbred BALB C biology Immunologic Deficiency Syndromes Immunosuppression General Medicine medicine.disease biology.organism_classification Virology Immunity Innate Mice Mutant Strains medicine.anatomical_structure Chronic Disease biology.protein Female Antibody |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1460-2377 0953-8178 |
| DOI: | 10.1093/intimm/3.5.427 |
| Popis: | Infection of several mouse strains with Trypanosoma cruzi stimulates high levels of T and B lymphocyte activities which persist during the chronic phase and is followed by specific immunosuppression and severe autoimmune pathology. Infected BALB.Xid mice carrying an X-linked mutation and lacking CD5 B cells, display poor B cell responses to T. cruzi infection, accompanied by low levels of specific and non-specific immunoglobulins in the serum. However, these animals control parasitemia, do not show the wasting observed in BALB/c mice, and develop almost no pathology early in the chronic phase. The infection of (BALB.Xid female x BALB/c male) F1 animals shows that immunodefective males behave like Xid animals in contrast to females which respond as normal BALB/c mice. These results indicate that the Xid locus controls lymphocyte responses, parasite clearance and pathology in experimental Chagas' disease. |
| Databáze: | OpenAIRE |
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