Protein intake in infancy and carotid intima media thickness at 5 years--a secondary analysis from a randomized trial
| Autor: | Dariusz, Gruszfeld, Martina, Weber, Monika, Nowakowska-Rysz, Roman, Janas, Rainer, Kozlik-Feldmann, Annick, Xhonneux, Clotilde, Carlier, Enrica, Riva, Elvira, Verduci, Ricardo, Closa-Monasterolo, Joaquin, Escribano, Anna, Dobrzanska, Berthold, Koletzko, F, Vecchi |
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| Rok vydání: | 2014 |
| Předmět: |
Blood Glucose
Male Pediatrics medicine.medical_specialty Low protein Medicine (miscellaneous) Blood Pressure Motor Activity Carotid Intima-Media Thickness Childhood obesity law.invention Body Mass Index Randomized controlled trial law Risk Factors medicine Humans Insulin cardiovascular diseases Insulin-Like Growth Factor I Infant Nutritional Physiological Phenomena Nutrition and Dietetics medicine.diagnostic_test biology Apolipoprotein A-I business.industry Infant Newborn Infant medicine.disease Lipids Infant Formula Europe Breast Feeding Intima-media thickness Cardiovascular Diseases Child Preschool Apolipoprotein B-100 cardiovascular system biology.protein Apolipoprotein A1 Female Dietary Proteins business Lipid profile Breast feeding Body mass index Follow-Up Studies |
| Zdroj: | Annals of nutritionmetabolism. 66(1) |
| ISSN: | 1421-9697 |
| Popis: | Background: Nutrition in childhood has an influence on the cardiovascular function later on in life. European Childhood Obesity Project is a multicenter, randomized clinical intervention trial examining the effect of early protein intake on later health outcomes, particularly adiposity and related disorders. The aim of the study was to examine the effect of nutritional intervention - different protein intake in infancy on carotid intima-media thickness (cIMT) at 5 years. The association of cardiovascular risk factors with cIMT was also assessed. Methods: Healthy term formula-fed infants in five European countries were enrolled either to the higher (HP) or to the lower (LP) protein group. Observational group consisted of breastfed infants. Plasma insulin, glucose, lipid profile, IGF-1, apolipoprotein A1 and B were measured as well as anthropometric parameters of parents and a child, blood pressure and physical activity. Results: No difference in cIMT between HP and LP group was observed. Insulin, HOMA-IR index and total IGF-1 were positively associated with cIMT but after adjustment for confounders only an inverse association between ApoA1 and positive between ApoB/ApoA1 and cIMT were significant. Conclusion: High versus low protein intake in infancy does not influence cIMT at 5 years. cIMT in healthy children at 5 years is associated with their apolipoprotein profile. |
| Databáze: | OpenAIRE |
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