Is There Any Association Between Clinical and Biochemical Hyperandrogenism in Women With Female Pattern Hair Loss?
| Autor: | Khalil Al Hamdi, Abbas Ali Mansour, Samih A Odhaib |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
bald
hair loss premenopausal women Physiology macromolecular substances Dermatology 030204 cardiovascular system & hematology Overweight 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Dehydroepiandrosterone sulfate Sex hormone-binding globulin medicine Internal Medicine androgenetic alopecia Acne Testosterone hirsutism biology business.industry Hyperandrogenism General Engineering Endocrinology/Diabetes/Metabolism androgens medicine.disease alopecia sex hormone binding globulin Hair loss chemistry testosterone biology.protein medicine.symptom androgen excess business 030217 neurology & neurosurgery |
| Zdroj: | Cureus |
| ISSN: | 2168-8184 |
| Popis: | Background The exact association between clinical and biochemical hyperandrogenism (HA) is heterogeneous and cannot be ascertained, especially in normoandrogenic women. Objectives Evaluate any association between clinical phenotypes and biochemical parameters of HA in premenopausal women with female pattern hair loss (FPHL). Materials and methods A cross-sectional observational study on 362 women, who were assessed for general characteristics, the different FPHL severities by Sinclair's score, hirsutism by modified Ferriman-Gallwey (mFG) score. Evaluation for biochemical HA included total, calculated free and bioavailable testosterone (TT), free testosterone (FT), and bioavailable testosterone (BT), respectively, and dehydroepiandrosterone sulfate. The variables of clinical HA were FPHL, hirsutism, and acne. Results The enrolled young premenopausal women's age range was (14-47 years). Around 78% were overweight or obese women. Eighty-percent of women had a mild FPHL, with a median of three years, where 2/3 of women had a duration |
| Databáze: | OpenAIRE |
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