Pharmacokinetics of the anti-inflammatory drug ximoprofen in healthy young and elderly subjects: comparison with elderly rheumatic patients
| Autor: | Chasseaud Lf, I. W. Taylor, A. Darragh, I. James, G. Dorf, T Taylor |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1991 |
| Předmět: |
Drug
Adult Male medicine.medical_specialty Aging medicine.drug_class media_common.quotation_subject Gastroenterology Anti-inflammatory chemistry.chemical_compound Pharmacokinetics Oral administration Internal medicine Rheumatic Diseases medicine Humans Pharmacology (medical) media_common Aged Pharmacology Aged 80 and over Creatinine Phenylpropionates business.industry Ximoprofen Anti-Inflammatory Agents Non-Steroidal Half-life Healthy elderly chemistry Anesthesia Female business Research Article Half-Life |
| Popis: | The pharmacokinetics of ximoprofen were studied in young and elderly subjects after single and repeated doses up to 30 mg. In healthy elderly subjects (30 mg dose), a mean peak plasma drug concentration of 1.78 micrograms ml-1 +/- 0.83 s.d. occurred at a mean time of 1.95 h +/- 1.40 s.d. and, thereafter, concentrations declined monoexponentially with a mean half-life of 3.8 h +/- 1.4 s.d. Comparison of these data with those from younger healthy subjects showed that peak drug concentrations, areas under the curve and half-lives were about two-fold greater in the elderly, these differences probably reflecting a lower systemic drug clearance. Similar results were obtained on comparing data from young healthy subjects and elderly rheumatic patients receiving single and repeated doses of ximoprofen (15 mg twice daily). In patients, the half-life of ximoprofen was 2.5 h +/- 0.7 s.d. Within either group, pharmacokinetic parameters after single or repeated doses were similar: ximoprofen did not accumulate in the plasma of the young or elderly. |
| Databáze: | OpenAIRE |
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