Assessment of Hypothalamic-Pituitary-Adrenal Axis Function After Corticosteroid Therapy in Inflammatory Bowel Disease
| Autor: | R Agher, Daniel Couturier, Jean-Marc Sabate, C Bremont, Marianne Gaudric, Stanislas Chaussade, J Desramé |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Hypothalamo-Hypophyseal System medicine.medical_specialty Multivariate analysis medicine.drug_class medicine.medical_treatment Pituitary-Adrenal System Disease Gastroenterology Inflammatory bowel disease Risk Factors Internal medicine medicine Humans In patient Retrospective Studies Immunosuppressive treatment Chemotherapy Hepatology business.industry Retrospective cohort study Inflammatory Bowel Diseases medicine.disease Ulcerative colitis Past history Surgery medicine.anatomical_structure Corticosteroid therapy Delayed-Action Preparations Cosyntropin Corticosteroid Female business Hypothalamic–pituitary–adrenal axis |
| Zdroj: | American Journal of Gastroenterology. 97:1785-1791 |
| ISSN: | 0002-9270 |
| DOI: | 10.1111/j.1572-0241.2002.05786.x |
| Popis: | OBJECTIVES: In patients with inflammatory bowel disease (IBD), little is known about the effect of long term corticosteroid therapy (CT) on the hypothalamic-pituitary-adrenal (HPA) axis function. Our aim was to assess HPA axis function in IBD, before the end of CT, during the tapering phase. METHODS: HPA axis function was assessed with cortisol (ng/ml) measurement before (T0) (normal > 100) and 60 min (normal > 210) after 0.25 mg tetracosactide (Synacthen immediat) injection (T60) in 55 consecutive cases of IBD attacks. Abnormal response was defined as a T60 |
| Databáze: | OpenAIRE |
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