Autor: |
Matthew Levy, Andrew D. Ellington, Michael G. Rosenblum, Sarah Faulkner, Laura A. Lavery, John W. Marks, Ted C. Chu |
Rok vydání: |
2023 |
Popis: |
We have used RNA aptamer:gelonin conjugates to target and specifically destroy cells overexpressing the known cancer biomarker prostate-specific membrane antigen (PSMA). Aptamer:toxin conjugates have an IC50 of 27 nmol/L and display an increased potency of at least 600-fold relative to cells that do not express PSMA. The aptamer not only promotes uptake into target cells but also decreases the toxicity of gelonin in non-target cells. These results validate the notion that “escort aptamers” may be useful for the treatment of specific tumors expressing unique antigen targets.(Cancer Res 2006; 66(12): 5989-92) |
Databáze: |
OpenAIRE |
Externí odkaz: |
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