Treatment of endometriosis in different ethnic populations: a meta-analysis of two clinical trials
| Autor: | Thomas Faustmann, Christian Seitz, Christoph Gerlinger, Jeffrey J Hassall |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Oncology
medicine.medical_specialty endocrine system Visual analogue scale Europe/Japan Endometriosis Ethnic populations Hormone antagonist lcsh:Gynecology and obstetrics Buserelin White People chemistry.chemical_compound Hormone Antagonists Asian People Japan Internal medicine Obstetrics and Gynaecology GnRH analogue Ethnic differences medicine Humans Nandrolone lcsh:RG1-991 Medicine(all) business.industry Dienogest lcsh:Public aspects of medicine Obstetrics and Gynecology lcsh:RA1-1270 General Medicine medicine.disease Clinical trial Europe Endocrinology Treatment Outcome Reproductive Medicine chemistry Meta-analysis Female Leuprolide business medicine.drug Research Article Progestogen/progestin |
| Zdroj: | BMC Women's Health BMC Women's Health, Vol 12, Iss 1, p 9 (2012) |
| ISSN: | 1472-6874 |
| Popis: | Approaches to the treatment of endometriosis vary worldwide, but studies comparing endometriosis medications in different ethnic groups are rare. A systematic literature search identified two studies directly comparing dienogest (DNG) versus gonadotropin-releasing hormone (GnRH) analogues in European and Japanese populations. Meta-analysis of visual analogue scale scores revealed no heterogeneity in response between the trials, indicating equivalent efficacy of DNG and GnRH analogues for endometriosis-related pain across populations. DNG was significantly superior to GnRH analogues for bone mineral density change in both trials, but significant heterogeneity between the studies may indicate ethnic differences in physiology. |
| Databáze: | OpenAIRE |
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