An Unusual Case of Congenital Primitive Neuroectodermal Tumor With Ocular Metastasis
| Autor: | Sara O. Vargas, Tobias Neff, Lindsay Frazier, Cristian M. Salgado, Deborah K. VanderVeen |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Vincristine Pathology medicine.medical_specialty genetic structures Bevacizumab Cyclophosphamide medicine.medical_treatment Soft Tissue Neoplasms Antibodies Monoclonal Humanized Metastasis Fatal Outcome Antineoplastic Combined Chemotherapy Protocols medicine Humans Neuroectodermal Tumors Primitive Chemotherapy business.industry Eye Neoplasms Infant Newborn Hematology medicine.disease Primary tumor eye diseases Oncology Doxorubicin Face Primitive neuroectodermal tumor Pediatrics Perinatology and Child Health Topotecan sense organs business medicine.drug |
| Zdroj: | Journal of Pediatric Hematology/Oncology. 34:e69-e71 |
| ISSN: | 1077-4114 |
| DOI: | 10.1097/mph.0b013e318221ca9b |
| Popis: | Primitive neuroectodermal tumor (PNET) is most common in the second decade of life. Congenital PNET is very rare. Ocular metastasis of PNET is likewise exceedingly rare; with only 5 previously published cases. We report an unusual congenital PNET of the face, which metastasized to subcutis, eyes, and brain. The primary tumor responded to chemotherapy (vincristine/doxorubicin/cyclophosphamide) with metachronous progression of ocular lesions. A therapeutic trial of intraocular bevacizumab showed no efficacy on intraocular lesions. Eventually the patient developed cerebral metastasis, and second line therapy with topotecan/cyclophosphamide was initiated. The tumor progressed and the patient died after acute herniation. |
| Databáze: | OpenAIRE |
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