Comparative effectiveness of antiepileptic drugs in juvenile myoclonic epilepsy
| Autor: | Silvennoinen K., de Lange N., Zagaglia S., Balestrini S., Androsova G., Wassenaar M., Auce P., Avbersek A., Becker F., Berghuis B., Campbell E., Coppola A., Francis B., Wolking S., Cavalleri G. L., Craig J., Delanty N., Johnson M. R., Koeleman B. P. C., Kunz W. S., Lerche H., Marson A. G., O'Brien T. J., Sander J. W., Sills G. J., Striano P., Zara F., van der Palen J., Krause R., Depondt C., Sisodiya S. M., Brodie M. J., Chinthapalli K., de Haan G. -J., Doherty C. P., Heavin S., McCormack M., Petrovski S., Sargsyan N., Slattery L., Willis J. |
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| Přispěvatelé: | National Institute for Health Research, Silvennoinen, K., de Lange, N., Zagaglia, S., Balestrini, S., Androsova, G., Wassenaar, M., Auce, P., Avbersek, A., Becker, F., Berghuis, B., Campbell, E., Coppola, A., Francis, B., Wolking, S., Cavalleri, G. L., Craig, J., Delanty, N., Johnson, M. R., Koeleman, B. P. C., Kunz, W. S., Lerche, H., Marson, A. G., O'Brien, T. J., Sander, J. W., Sills, G. J., Striano, P., Zara, F., van der Palen, J., Krause, R., Depondt, C., Sisodiya, S. M., Brodie, M. J., Chinthapalli, K., de Haan, G. -J., Doherty, C. P., Heavin, S., Mccormack, M., Petrovski, S., Sargsyan, N., Slattery, L., Willis, J. |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Topiramate
Pediatrics medicine.medical_specialty Neurology [D14] [Human health sciences] seizure adverse drug reaction Clinical Neurology Lamotrigine lcsh:RC346-429 03 medical and health sciences Epilepsy 0302 clinical medicine Journal Article medicine 030212 general & internal medicine EpiPGX Consortium tolerability lcsh:Neurology. Diseases of the nervous system seizures adverse drug reactions Neurologie [D14] [Sciences de la santé humaine] business.industry Weight change Généralités Carbamazepine medicine.disease 3. Good health valproate Neurology Tolerability Full‐length Original Research Neurology (clinical) Levetiracetam Juvenile myoclonic epilepsy business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Epilepsia Open Epilepsia Open, 4(3), 420. Wiley-Blackwell Publishing Ltd Epilepsia Open, 4(3), 420-430. Wiley-Blackwell Epilepsia Open, 4 (3 EPILEPSIA OPEN Epilepsia Open, Vol 4, Iss 3, Pp 420-430 (2019) Epilepsia Open, 0(0). (2019). |
| ISSN: | 2470-9239 |
| Popis: | Objective: To study the effectiveness and tolerability of antiepileptic drugs (AEDs) commonly used in juvenile myoclonic epilepsy (JME). Methods: People with JME were identified from a large database of individuals with epilepsy, which includes detailed retrospective information on AED use. We assessed secular changes in AED use and calculated rates of response (12-month seizure freedom) and adverse drug reactions (ADRs) for the five most common AEDs. Retention was modeled with a Cox proportional hazards model. We compared valproate use between males and females. Results: We included 305 people with 688 AED trials of valproate, lamotrigine, levetiracetam, carbamazepine, and topiramate. Valproate and carbamazepine were most often prescribed as the first AED. The response rate to valproate was highest among the five AEDs (42.7%), and significantly higher than response rates for lamotrigine, carbamazepine, and topiramate; the difference to the response rate to levetiracetam (37.1%) was not significant. The rates of ADRs were highest for topiramate (45.5%) and valproate (37.5%). Commonest ADRs included weight change, lethargy, and tremor. In the Cox proportional hazards model, later start year (1.10 [1.08-1.13], P SCOPUS: ar.j info:eu-repo/semantics/published |
| Databáze: | OpenAIRE |
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