Regional brain atrophy in cognitively intact adults with a single APOE epsilon4 allele
| Autor: | Robert M. Roth, Brenna C. McDonald, Thomas W. McAllister, Heather A. Wishart, Laura A. Rabin, Andrew J. Saykin, Alexander C. Mamourian, Laura A. Flashman, Gregory J. Tsongalis, C. H. Rhodes |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Apolipoprotein E
Adult Male Pathology medicine.medical_specialty Apolipoprotein E4 DNA Mutational Analysis Audiology computer.software_genre Statistical parametric mapping Atrophy Apolipoproteins E Gene Frequency Voxel Genotype medicine Humans Genetic Predisposition to Disease Allele Allele frequency Aged General linear model Aged 80 and over Neurons Brain Middle Aged medicine.disease Magnetic Resonance Imaging Mutation Female Neurology (clinical) Psychology Cognition Disorders computer |
| Zdroj: | Neurology. 67(7) |
| ISSN: | 1526-632X |
| Popis: | To determine whether cognitively intact adults with the APOE epsilon3/epsilon4 genotype show reduced gray matter density on voxel-based morphometry (VBM) vs those homozygous for the epsilon3 allele.Participants were healthy, cognitively intact, right-handed adults, age 19 to 80, who completed genotyping, neuropsychological testing, and MRI. Forty-nine participants had the epsilon3/epsilon3 genotype and 27 had the epsilon3/epsilon4 genotype. Gray matter data were analyzed using the general linear model as implemented in the Statistical Parametric Mapping package, adjusting for age and sex.The epsilon3/epsilon4 participants showed lower gray matter density than the epsilon3/epsilon3 participants in right medial temporal and bilateral frontotemporal regions as well as other areas. There were no regions in which epsilon3/epsilon4 participants showed higher gray matter density than epsilon3/epsilon3 participants.Regionally reduced gray matter density is detectable in cognitively intact adults with a single copy of the APOE epsilon4 allele. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|