Incidence And Risk Factors Of Contrast Nephropathy After Tace In Patients With Liver Cancer And Chronic Kidney Disease
| Autor: | Ning Ding, Kun-Kun Cao, Jiaming Zhong, Xiao-Li Zhang, Jian Zhai, Zengqiang Qu, Xiao-We Li |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Carcinoma Hepatocellular Serum albumin Contrast-induced nephropathy Contrast Media Gastroenterology Nephropathy chemistry.chemical_compound Risk Factors Internal medicine Humans Medicine Chemoembolization Therapeutic Renal Insufficiency Chronic Adverse effect Retrospective Studies Creatinine biology business.industry Incidence Liver Neoplasms General Medicine medicine.disease chemistry Hepatocellular carcinoma biology.protein business Liver cancer Kidney disease |
| Zdroj: | Clinical and Investigative Medicine. 44:E19-24 |
| ISSN: | 1488-2353 |
| DOI: | 10.25011/cim.v44i3.36961 |
| Popis: | Purpose: Incidence of contrast induced nephropathy (CIN) and related risk factors in patients with liver cancer and chronic kidney disease after trans-catheter arterial chemoembolization (TACE) is higher. The purpose of this study was to investigate the feasibility and safety of TACE therapy in such patients. Methods: A retrospective analysis was performed on 103 patients with liver cancer and chronic kidney disease who underwent TACE treatments. TACE was performed according to Seldinger’s technique of arterial embolization with minor modifications. Based on CIN diagnostic criteria, patients were divided into non-CIN (n=89) and CIN (n=14) groups. Multiple clinical parameters were assessed for the two groups after TACE. Serum creatinine levels were measured 48-72 h after TACE. Results: Tumor size (>5 cm), TACE frequency, contrast agent dosage, solitary kidney, volume of iodized oil used in the TACE (ml) and urea levels were significantly higher in CIN group in comparison with the non-CIN group, while serum albumin and haemoglobin levels were significantly lower. Multivariate logistic regression analysis confirmed that the volume of iodized oil and TACE frequency were significantly positively correlated, and serum albumin level was negatively correlated in the CIN group. Conclusion: Volume of iodized oil, TACE frequency and low serum albumin levels were found to be independent risk factors for CIN after TACE. Thus, it is safe and feasible for hepatocellular carcinoma patients with chronic kidney disease to receive TACE treatment, but adverse events management after TACE needs to be addressed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|