Prevalence of HBeAg, anti-HBe serological markers and HBV-DNA in asymptomatic carriers in Ethiopia
| Autor: | G. B. Rossi, Anna Rita Ciccaglione, A. M. Di Rienzo, L. Bisanti, D. Bekura, G. Morace, K. Hailu, M. Rapicetta, Paolo Pasquini |
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| Rok vydání: | 1989 |
| Předmět: |
Adult
Male Hepatitis B virus HBsAg medicine.medical_specialty Asia Adolescent Epidemiology Population Radioimmunoassay medicine.disease_cause Serology Prevalence Humans Medicine Hepatitis B e Antigens Hepatitis B Antibodies education education.field_of_study business.industry Nucleic Acid Hybridization virus diseases Hepatitis B Virology digestive system diseases HBeAg Carrier State DNA Viral Immunology Female Ethiopia business Asymptomatic carrier Biomarkers Horizontal transmission |
| Zdroj: | European Journal of Epidemiology. 5:481-485 |
| ISSN: | 1573-7284 0393-2990 |
| DOI: | 10.1007/bf00140145 |
| Popis: | Data on the distribution of HBV-DNA and other serological markers of hepatitis B virus infection in a population of asymptomatic carriers in Ethiopia are reported. As compared to data from other countries of similar or lower levels of endemicity, it has been found that HBV-DNA prevalence and its correlation with HBeAg/anti-HBe status is similar to that of northern Europe. HBV-DNA is present in 84% of HBe Ag-positive sera but in only 4% of anti-HBe-positive sera, where the lowest concentration of DNA (less than 5 pgr/20 microliters) was found. The trend of increasing prevalence of serological markers with age seems to indicate a considerable horizontal transmission still present in this age range (18-30). In keeping with data of other authors a 3% of HBV-DNA positivity in anti HBc only positive sera was found. No regional or ethnical differences of HBV-DNA positive sera across the country were observed. There is also no evidence of any correlation between HBV-DNA prevalence and HBsAg subtypes ad and ay. |
| Databáze: | OpenAIRE |
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