Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium

Autor: Robert F. Krueger, Teresa Nutile, Georg Homuth, Ina Giegling, Aarno Palotie, Katja Appel, Grant W. Montgomery, Elisabeth Widen, Jouke-Jan Hottenga, Beate St Pourcain, Caroline Hayward, Andrea Maschio, Andrew C. Heath, Narelle K. Hansell, Terho Lehtimäki, Wendy S. Slutske, Sarah E. Medland, Johan G. Eriksson, John M. Starr, Antonio Terracciano, Jonathan Marten, Olli T. Raitakari, Liisa Keltikangas-Järvinen, Igor Rudan, Kati Heinonen, Brenda W.J.H. Penninx, David J. Porteous, Klaasjan G. Ouwens, Barbara Franke, Jaakko Kaprio, Erik Pettersson, Jueri Allik, Ian J. Deary, Alessandra Minelli, Nicholas G. Martin, William G. Iacono, Yuri Milaneschi, Ilkka Seppälä, David M. Evans, Lina Zgaga, John P. Kemp, Alexander Teumer, Dorret I. Boomsma, Harry Campbell, Margaret J. Wright, Abraham A. Palmer, Jun Ding, Patrik K. E. Magnusson, Marleen H. M. de Moor, James F. Wilson, Anu Realo, Paul T. Costa, Scott D. Gordon, Jaime Derringer, Michel G. Nivard, Cornelia M. van Duijn, David C. Liewald, David Schlessinger, Marina Ciullo, Juho Wedenoja, Amy B. Hart, Laura J. Bierut, Angelina R. Sutin, Hamdi Mbarek, Alexander Viktorin, Stéphanie Martine van den Berg, Ozren Polasek, Harriet de Wit, Jari Lahti, Dan Rujescu, Nicholas J. Timpson, Matthias Nauck, Fabio Busonero, Iryna O. Fedko, Evelin Mihailov, Gonçalo R. Abecasis, John M. Hettema, Daniel E. Adkins, Hans J. Grabe, Richard A. Grucza, Luigi Ferrucci, Alejandro Arias Vasquez, Barbara E. Engelhardt, Laura Pulkki-Råback, Antti Latvala, Bettina Konte, Michelle Luciano, Robert Karlsson, Chiara Magri, Sita H. Vermeulen, Tõnu Esko, Arpana Agrawal, Matt McGue, Holly Trochet, Joost G. E. Janzing, Gail Davies, Toshiko Tanaka, Rossella Sorice, Timothy B. Bigdeli, Abdel Abdellaoui, Karin J. H. Verweij, Andres Metspalu, Nancy L. Pedersen, Anjali K. Henders, Matthew G. Kirkpatrick, Yong Qian, Lindsay K. Matteson, Annette M. Hartmann, George Davey Smith, Michael B. Miller, Najaf Amin, Pamela A. F. Madden, Richard J. Rose, Minyoung Lee, Eero Vuoksimaa, Katri Räikkönen, Markus Jokela, Jennifer E. Huffman, Carsten Oliver Schmidt, Jasper Wouda, Daniela Ruggiero
Přispěvatelé: Academic Medical Center, Helsinki Collegium for Advanced Studies, Behavioural Sciences, Clinicum, Department of Public Health, Johan Eriksson / Principal Investigator, Department of General Practice and Primary Health Care, Diabetes and Obesity Research Program, Research Programs Unit, Institute for Molecular Medicine Finland, Aarno Palotie / Principal Investigator, Elisabeth Ingrid Maria Widen / Principal Investigator, Jaakko Kaprio / Principal Investigator, Psychosocial factors and health, Developmental Psychology Research Group, Genomics of Neurological and Neuropsychiatric Disorders, Genetic Epidemiology, Genomic Discoveries and Clinical Translation, Faculty of Behavioural, Management and Social Sciences, Psychiatry, EMGO - Mental health, Amsterdam Neuroscience - Complex Trait Genetics, IOO, EMGO+ - Mental Health, Biological Psychology, Clinical Child and Family Studies, Erasmus MC other, Epidemiology
Jazyk: angličtina
Rok vydání: 2016
Předmět:
0301 basic medicine
Netherlands Twin Register (NTR)
Multifactorial Inheritance
Genome-wide association study
Cohort Studies
Extraversion
Psychological
0302 clinical medicine
Risk Factors
NEUROTICISM
Genetics(clinical)
IR-99241
Big Five personality traits
Genetics (clinical)
Original Research
media_common
Genetics
Ecology
HERITABILITY
METIS-315471
Polymorphism
Single Nucleotide/genetics
Neuroticism
3142 Public health care science
environmental and occupational health
Common genetic variants
Urological cancers Radboud Institute for Health Sciences [Radboudumc 15]
Trait
Psychology
Personality
DIMENSIONS
NEUROTROPHIC FACTOR BDNF
Evolution
515 Psychology
media_common.quotation_subject
Single-nucleotide polymorphism
Phenotype harmonization
Polymorphism
Single Nucleotide
Imputation
Polygenic risk
Ecology
Evolution
Behavior and Systematics
03 medical and health sciences
Behavior and Systematics
Personality/genetics
CLONINGERS TEMPERAMENT SCALES
5-FACTOR MODEL
Humans
Multifactorial Inheritance/genetics
PSYCHOBIOLOGICAL MODEL
Extraversion and introversion
Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7]
Other Research Radboud Institute for Health Sciences [Radboudumc 0]
Extraversion (Psychology)
COMMON SNPS EXPLAIN
030104 developmental biology
LARGE PROPORTION
3111 Biomedicine
Developmental Psychopathology
HUMAN HEIGHT
030217 neurology & neurosurgery
Genome-Wide Association Study
Zdroj: Behavior Genetics
van den Berg, S M, de Moor, M H M, Verweij, C J H, Krueger, R F, Luciano, M, Vasquez, A A, Matteson, L K, Derringer, J, Esko, T, Amin, N, Gordon, S D, Hansell, N K, Hart, A B, Seppälä, I, Huffman, J E, Konte, B, Lahti, J, Miller, M, Nutile, T, Tanaka, T, Teumer, A, Viktorin, A, Wedenoja, J, Abdellaoui, A, Abecasis, G R, Adkins, D E, Agrawal, A, Allik, J, Appel, K, Bigdeli, T B, Busonero, F, Campbell, H, Costa, P T, Davey Smith, G, Davies, G, de Wit, H, Ding, J, Engelhardt, B E, Eriksson, J G, Fedko, I O, Ferrucci, L, Franke, B, Giegling, I, Grucza, R, Hartmann, A M, Heath, A C, Heinonen, K, Henders, A K, Homuth, G, Hottenga, J J, Iacono, W G, Janzing, J, Jokela, M, Karlsson, R, Kemp, J P, Kirkpatrick, M G, Latvala, A, Lehtimäki, T, Liewald, D C, Madden, P A F, Magri, C, Magnusson, P K E, Marten, J, Maschio, A, Mbarek, H, Medland, S E, Mihailov, E, Milaneschi, Y, Montgomery, G W, Nauck, M, Nivard, M G, Ouwens, K G, Palotie, A, Pettersson, E, Polasek, O, Qian, Y, Pulkki-Raback, L, Raitakari, O T, Realo, A, Rose, R J, Ruggiero, D, Schmidt, C O, Slutske, W S, Sorice, R, Starr, J M, St Pourcain, B, Sutin, A R, Timpson, N J, Trochet, H, Zgaga, L, Porteous, D, Minelli, A, Palmer, A A, Rujescu, D, Ciullo, M, Hayward, C, Rudan, I, Metspalu, A, Kaprio, J, Deary, I J, Räikkönen, K, Wilson, J F, Keltikangas-Järvinen, L, Bierut, L J, Hettema, J M, Grabe, H J, Penninx, B W J H, van Duijn, C M, Evans, D M, Schlessinger, D, Pedersen, N L, Terracciano, A, McGue, M, Martin, N G & Boomsma, D I 2016, ' Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium ', Behavior Genetics, vol. 46, no. 2, pp. 170-182 . https://doi.org/10.1007/s10519-015-9735-5
Behavior genetics, 46(2), 170-182. Springer New York
Behavior Genetics, 46, 2, pp. 170-82
Behavior genetics (2015). doi:10.1007/s10519-015-9735-5
info:cnr-pdr/source/autori:van Den Berg S.M.; de Moor M.H.M.; Verweij K.J.H.; Krueger R.F.; Luciano M.; Arias Vasquez A.; Matteson L.K.; Derringer J.; Esko T.; Amin N.; Gordon S.D.; Hansell N.K.; Hart A.B.; Seppala I.; Huffman J.E.; Konte B.; Lahti J.; Lee M.; Miller M.; Nutile T.; Tanaka T.; Teumer A.; Viktorin A.; Wedenoja J.; Abdellaoui A.; Abecasis G.R.; Adkins D.E.; Agrawal A.; Allik J.; Appel K.; Bigdeli T.B.; Busonero F.; Campbell H.; Costa P.T.; Smith G.D.; Davies G.; de Wit H.; Ding J.; Engelhardt B.E.; Eriksson J.G.; Fedko I.O.; Ferrucci L.; Franke B.; Giegling I.; Grucza R.; Hartmann A.M.; Heath A.C.; Heinonen K.; Henders A.K.; Homuth G.; Hottenga J.-J.; Iacono W.G.; Janzing J.; Jokela M.; Karlsson R.; Kemp J.P.; Kirkpatrick M.G.; Latvala A.; Lehtimaki T.; Liewald D.C.; Madden P.A.F.; Magri C.; Magnusson P.K.E.; Marten J.; Maschio A.; Mbarek H.; Medland S.E.; Mihailov E.; Milaneschi Y.; Montgomery G.W.; Nauck M.; Nivard M.G.; Ouwens K.G.; Palotie A.; Pettersson E.; Polasek O.; Qian Y.; Pulkki-Raback L.; Raitakari O.T.; Realo A.; Rose R.J.; Ruggiero D.; Schmidt C.O.; Slutske W.S.; Sorice R.; Starr J.M.; St Pourcain B.; Sutin A.R.; Timpson N.J.; Trochet H.; Vermeulen S.; Vuoksimaa E.; Widen E.; Wouda J.; Wright M.J.; Zgaga L.; Generation Scotland; Porteous D.; Minelli A.; Palmer A.A.; Rujescu D.; Ciullo M.; Hayward C.; Rudan I.; Metspalu A.; Kaprio J.; Deary I.J.; Raikkonen K.; Wilson J.F.; Keltikangas-Jarvinen L.; Bierut L.J.; Hettema J.M.; Grabe H.J.; Penninx B.W.J.H.; van Duijn C.M.; Evans D.M.; Schlessinger D.; Pedersen N.L.; Terracciano A.; McGue M.; Martin N.G.; Boomsma D.I./titolo:Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium/doi:10.1007%2Fs10519-015-9735-5/rivista:Behavior genetics/anno:2015/pagina_da:/pagina_a:/intervallo_pagine:/volume
van den Berg, S M, de Moor, M H M, Verweij, K J H, Krueger, R F, Luciano, M, Arias Vasquez, A, Matteson, L K, Derringer, J, Esko, T, Amin, N, Gordon, S D, Hansell, N K, Hart, A B, Seppälä, I, Huffman, J E, Konte, B, Lahti, J, Lee, M, Miller, M, Nutile, T, Tanaka, T, Teumer, A, Viktorin, A, Wedenoja, J, Abdellaoui, A, Abecasis, G R, Adkins, D E, Agrawal, A, Allik, J, Appel, K, Bigdeli, T B, Busonero, F, Campbell, H, Costa, P T, Smith, G D, Davies, G, de Wit, H, Ding, J, Engelhardt, B E, Eriksson, J G, Fedko, I O, Ferrucci, L, Franke, B, Giegling, I, Grucza, R, Kemp, J P, Medland, S E, St Pourcain, B, Timpson, N J, Evans, D M 2016, ' Meta-analysis of Genome-Wide Association Studies for Extraversion : Findings from the Genetics of Personality Consortium ', Behavior Genetics, vol. 46, no. 2, pp. 170-182 . https://doi.org/10.1007/s10519-015-9735-5
Behavior Genetics, 46, 170-182
Behavior genetics, 46(2), 170-182. Springer
Behavior Genetics, 46(2), 170-182. Springer US
Behavior Genetics, 46(2), 170-182. Springer
Behavior Genetics, 46, 170-82
van den Berg, S M, de Moor, M H M, Verweij, K J H, Krueger, R F, Luciano, M, Vasquez, A A, Matteson, L K, Derringer, J, Esko, T, Amin, N, Gordon, S D, Hansell, N K, Hart, A B, Seppala, I, Huffman, J E, Konte, B, Lahti, J, Lee, M, Miller, M, Nutile, T, Tanaka, T, Teumer, A, Viktorin, A, Wedenoja, J, Abdellaoui, A, Abecasis, G R, Adkins, D E, Agrawal, A, Allik, J, Appel, K, Bigdeli, T B, Busonero, F, Campbell, H, Costa, P T, Smith, G D, Davies, G, de Wit, H, Ding, J, Engelhardt, B E, Eriksson, J G, Fedko, I O, Ferrucci, L, Franke, B, Giegling, I, Grucza, R, Hartmann, A M, Heath, A C, Heinonen, K, Henders, A K, Homuth, G, Hottenga, J-J, Iacono, W G, Janzing, J, Jokela, M, Karlsson, R, Kemp, J P, Kirkpatrick, M G, Latvala, A, Lehtimaki, T, Liewald, D C, Madden, P A F, Magri, C, Magnusson, P K E, Marten, J, Maschio, A, Mbarek, H, Medland, S E, Mihailov, E, Milaneschi, Y, Montgomery, G W, Nauck, M, Nivard, M G, Ouwens, K G, Palotie, A, Pettersson, E, Polasek, O, Qian, Y, Pulkki-Raback, L, Raitakari, O T, Realo, A, Rose, R J, Ruggiero, D, Schmidt, C O, Slutske, W S, Sorice, R, Starr, J M, St Pourcain, B, Sutin, A R, Timpson, N J, Trochet, H, Vermeulen, S, Vuoksimaa, E, Widen, E, Wouda, J, Wright, M J, Zgaga, L, Porteous, D, Minelli, A, Palmer, A A, Rujescu, D, Ciullo, M, Hayward, C, Rudan, I, Metspalu, A, Kaprio, J, Deary, I J, Raikkonen, K, Wilson, J F, Keltikangas-Jarvinen, L, Bierut, L J, Hettema, J M, Grabe, H J, Penninx, B W J H, van Duijn, C M, Evans, D M, Schlessinger, D, Pedersen, N L, Terracciano, A, McGue, M, Martin, N G & Boomsma, D I 2016, ' Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium ', Behavior Genetics, vol. 46, no. 2, pp. 170-182 . https://doi.org/10.1007/s10519-015-9735-5
Behavior Genetics, 46(2), 170-182. Springer New York
van den Berg, S M, de Moor, M H M, Verweij, K J H, Krueger, R F, Luciano, M, Arias Vasquez, A, Matteson, L K, Derringer, J, Esko, T, Amin, N, Gordon, S D, Hansell, N K, Hart, A B, Seppälä, I, Huffman, J E, Konte, B, Lahti, J, Lee, M, Miller, M, Nutile, T, Tanaka, T, Teumer, A, Viktorin, A, Wedenoja, J, Abdellaoui, A, Abecasis, G R, Adkins, D E, Agrawal, A, Allik, J, Appel, K, Bigdeli, T B, Busonero, F, Campbell, H, Costa, P T, Smith, G D, Davies, G, de Wit, H, Ding, J, Engelhardt, B E, Eriksson, J G, Fedko, I O, Liewald, D C, Polasek, O, Starr, J M, Zgaga, L, Porteous, D, Hayward, C, Rudan, I & Deary, I J & Wilson, J F 2015, ' Meta-analysis of genome-wide association studies for extraversion : Findings from the Genetics of Personality Consortium ', Behavior Genetics . https://doi.org/10.1007/s10519-015-9735-5
van den Berg, S M, de Moor, M H M, Verweij, K J H, Krueger, R F, Luciano, M, Arias Vasquez, A, Matteson, L K, Derringer, J, Esko, T, Amin, D N, Gordon, S D, Hansell, N K, Hart, A B, Seppälä, I, Huffman, J E, Konte, B, Lahti, J, Lee, J M, Miller, M, Nutile, T, Tanaka, T, Teumer, A, Viktorin, A, Wedenoja, J, Abdellaoui, A, Abecasis, G R, Adkins, D E, Agrawal, A, Allik, J, Appel, K, Bigdeli, T B, Busonero, F, Campbell, H, Costa, P T, Smith, G D, Davies, G, De Wit, H, Ding, J Z, Engelhardt, B E, Eriksson, J G, Fedko, I O, Ferrucci, L, Franke, B, Giegling, I, Grucza, R, Hartmann, A M, Heath, A C, Heinonen, K, Henders, A K, Homuth, G, Hottenga, J J, Iacono, W G, Janzing, J, Jokela, M, Karlsson, R, Kemp, J P, Kirkpatrick, M G, Latvala, A, Lehtimäki, T, Liewald, D C, Madden, P A F, Magri, C, Magnusson, P K E, Marten, J, Maschio, A, Mbarek, H, Medland, S E, Mihailov, E, Milaneschi, Y, Montgomery, G W, Nauck, M, Nivard, M G, Ouwens, K G, Palotie, A, Pettersson, E, Polasek, O, Qian, Y-P, Pulkki-Råback, L, Raitakari, O T, Realo, A, Rose, R J, Ruggiero, D, Schmidt, C O, Slutske, W S, Sorice, R, Starr, J M, St Pourcain, B, Sutin, A R, Timpson, N J, Trochet, H, Vermeulen, S H, Vuoksimaa, E, Widen, E, Wouda, J, Wright, M J, Zgaga, L, Generation, S, Porteous, D J, Minelli, A, Palmer, L A, Rujescu, D, Ciullo, M, Hayward, C, Rudan, I, Metspalu, A, Kaprio, J, Deary, I J, Räikkönen, K, Wilson, J F, Keltikangas-Järvinen, L, Bierut, L J, Hettema, J M, Grabe, H-J, Penninx, B W J H, van Duijn, C M, Evans, D M, Schlessinger, D, Pedersen, N L, Terracciano, A, McGue, M, Martin, N G & Boomsma, D I 2016, ' Meta-analysis of Genome-Wide Association Studies for Extraversion : Findings from the Genetics of Personality Consortium ', Behavior Genetics, vol. 46, no. 2, pp. 170-182 . https://doi.org/10.1007/s10519-015-9735-5
Behavior Genetics, 46, 2, pp. 170-182
ISSN: 0001-8244
1019-2816
DOI: 10.1007/s10519-015-9735-5
Popis: Extraversion is a relatively stable and heritable personality trait associated with numerous psychosocial, lifestyle and health outcomes. Despite its substantial heritability, no genetic variants have been detected in previous genome-wide association (GWA) studies, which may be due to relatively small sample sizes of those studies. Here, we report on a large meta-analysis of GWA studies for extraversion in 63,030 subjects in 29 cohorts. Extraversion item data from multiple personality inventories were harmonized across inventories and cohorts. No genome-wide significant associations were found at the single nucleotide polymorphism (SNP) level but there was one significant hit at the gene level for a long non-coding RNA site (LOC101928162). Genome-wide complex trait analysis in two large cohorts showed that the additive variance explained by common SNPs was not significantly different from zero, but polygenic risk scores, weighted using linkage information, significantly predicted extraversion scores in an independent cohort. These results show that extraversion is a highly polygenic personality trait, with an architecture possibly different from other complex human traits, including other personality traits. Future studies are required to further determine which genetic variants, by what modes of gene action, constitute the heritable nature of extraversion. © 2015, The Author(s). Extraversion is a relatively stable and heritable personality trait associated with numerous psychosocial, lifestyle and health outcomes. Despite its substantial heritability, no genetic variants have been detected in previous genome-wide association (GWA) studies, which may be due to relatively small sample sizes of those studies. Here, we report on a large meta-analysis of GWA studies for extraversion in 63,030 subjects in 29 cohorts. Extraversion item data from multiple personality inventories were harmonized across inventories and cohorts. No genome-wide significant associations were found at the single nucleotide polymorphism (SNP) level but there was one significant hit at the gene level for a long non-coding RNA site (LOC101928162). Genome-wide complex trait analysis in two large cohorts showed that the additive variance explained by common SNPs was not significantly different from zero, but polygenic risk scores, weighted using linkage information, significantly predicted extraversion scores in an independent cohort. These results show that extraversion is a highly polygenic personality trait, with an architecture possibly different from other complex human traits, including other personality traits. Future studies are required to further determine which genetic variants, by what modes of gene action, constitute the heritable nature of extraversion.
Databáze: OpenAIRE
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