Aurora A is differentially expressed and regulated in chromosomal and microsatellite instable sporadic colorectal cancers

Autor: Matthias Müller, Silke Lassmann, Ulrich T. Hopt, Mihai Danciu, Martin Werner, Frank Makowiec, Jürgen Schulte-Mönting, Roland Weis
Rok vydání: 2009
Předmět:
Adenoma
Male
medicine.medical_specialty
Pathology
Gene Dosage
Aneuploidy
Protein Serine-Threonine Kinases
Biology
medicine.disease_cause
Polymerase Chain Reaction
Gene dosage
Gene Expression Regulation
Enzymologic
Pathology and Forensic Medicine
Aurora Kinases
Chromosomal Instability
Chromosome instability
Gene duplication
medicine
Humans
Neoplasm Invasiveness
RNA
Messenger
In Situ Hybridization
Fluorescence
Aged
Cell Proliferation
Neoplasm Staging
Aged
80 and over
medicine.diagnostic_test
Carcinoma
Gene Amplification
Cytogenetics
Microsatellite instability
Middle Aged
medicine.disease
Immunohistochemistry
Molecular biology
Gene Expression Regulation
Neoplastic
Cell Transformation
Neoplastic
Case-Control Studies
Female
Microsatellite Instability
Colorectal Neoplasms
Carcinogenesis
Fluorescence in situ hybridization
Zdroj: Modern Pathology. 22:1385-1397
ISSN: 0893-3952
DOI: 10.1038/modpathol.2009.111
Popis: The centrosome-associated kinase aurora A has been shown to be involved in genetic instability and to be (over)expressed in several human carcinomas. This study investigated aurora A gene copy numbers, mRNA and protein expression as well as tumour cell proliferation and aneuploidy in chromosomal and microsatellite instable sporadic colorectal cancers. Case-matched tissues of normal (n=71) and dysplastic (n=49) colorectal epithelium and invasive carcinomas (n=71) were included in this study. PCR-based microsatellite analysis classified 14/71 (20%) of carcinomas as microsatellite instable. A stepwise increase of aurora A mRNA expression (P
Databáze: OpenAIRE
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