Cytogenetic findings in 14 benign cartilaginous neoplasms
| Autor: | Alessandra de La Roque Ferreira, Nilo Sakai Junior, Lia Menezes Formigli, Kikue Terada Abe, Maria Dulce Valverde de Oliveira, Marcio Fernandes Pereira, Déborah Afonso Cornélio, Ricardo Karam Kalil |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male congenital hereditary and neonatal diseases and abnormalities Cancer Research medicine.medical_specialty Pathology Conventional cytogenetics Adolescent Chromosomal translocation Biology Translocation Genetic Genetics Enchondroma medicine Humans Single institution Child Molecular Biology In Situ Hybridization Fluorescence Chromosome 13 Chromosome Aberrations Cytogenetics Chromosome Infant Middle Aged medicine.disease Child Preschool Karyotyping Neoplastic Processes Female Chondroma |
| Zdroj: | Cancer genetics. 204(4) |
| ISSN: | 2210-7762 |
| Popis: | Benign cartilaginous tumors represent a spectrum of neoplastic processes with variable clinical and pathologic presentations. These tumors are histologically characterized by the presence of chondrocytes surrounded by a cartilaginous matrix. Few studies describe karyotypic abnormalities in these benign lesions. We report a series of 14 chondromas from a single institution. Conventional cytogenetics was performed on short term cultures from all cases. Clonal chromosome aberrations were found in nine tumors. One soft tissue chondroma contained three clones with t(6;12)(q12;p11.2), t(3;7)(q13;p12), and der(2)t(2;18)(p11.2;q11.2). Three periosteal chondromas displayed random structural aberrations of chromosomes 2, 3, 6, 7, and 11 and loss of chromosome 13. Among the enchondromas, three tumors displayed chromosome losses, one contained a complex translocation involving chromosomes 12, 15, and 21 as well as an inv(2)(p21q31),t(12;15;21)(q13;q14;q22) and a separate enchondroma showed a translocation involving chromosomes 12 and 22. Our data suggest that considerable cytogenetic heterogeneity exists among benign chondromatous tumors. |
| Databáze: | OpenAIRE |
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