Density of neoplastic lymphoid infiltrate, CD8+ T cells, and CD1a+ dendritic cells in mycosis fungoides
| Autor: | G. Fabris, Daniela Stramazzotti, S. Rupoli, B. Mannello, Gaia Goteri, P. Leoni, A Filosa |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Skin Neoplasms CD8-Positive T-Lymphocytes Biology Immunophenotyping Pathology and Forensic Medicine Antigens CD1 Lymphocytes Tumor-Infiltrating Mycosis Fungoides Antigen Biopsy medicine Humans Cytotoxic T cell Aged Neoplasm Staging Mycosis fungoides integumentary system medicine.diagnostic_test Tumor-infiltrating lymphocytes hemic and immune systems Dendritic Cells Original Articles General Medicine Dendritic cell Middle Aged medicine.disease Langerhans Cells Female CD8 |
| Zdroj: | Journal of Clinical Pathology. 56:453-458 |
| ISSN: | 0021-9746 |
| Popis: | Background/Aims: CD8+ T cells and epidermal/dermal dendritic cells expressing CD1a are found among neoplastic CD4+ T cells in mycosis fungoides (MF) lesions. This study analysed the relation of CD8+ tumour infiltrating lymphocytes (TILs), CD1a+ epidermal Langerhan’s cells (LCs), and dermal dendritic cells (DDCs) to clinicopathological parameters in 46 MF cases. Methods: Pretreatment diagnostic biopsy specimens of 46 MF cases were submitted to histological analysis and immunohistochemistry. Four histological grades were defined based on the density of the neoplastic infiltrate: grade 1 (mild superficial perivascular infiltrate), grade 2 (moderate superficial perivascular infiltrate with some tendency to confluence), grade 3 (pronounced superficial band-like infiltrate), and grade 4 (deep nodular infiltrate). Epidermotropism was scored as low, moderate, or high. Numbers of CD8+ T cells and of dermal and epidermal CD1a+ cells were scored as 1 (low), 2 (moderate), and 3 (high). Correlations between these parameters and clinical data (age, sex, clinical type of lesions, stage, response to treatment, and recurrence) were analysed by the χ 2 test. Results: Numbers of TILs and DDCs were associated with subepidermal infiltrates, being lower in less dense infiltrates, whereas there was no association between epidermal CD1a+ cells and the analysed parameters. Complete remission in treated patients was related to subepidermal infiltrates but not to TILs, LCs, or DDCs. Conclusions: These results support the notion that CD8+ cells and dermal CD1a+ cells are active against tumour cells. MF with low numbers of TILs could represent an early stage of the disease, before TILs are activated against tumour specific antigens. |
| Databáze: | OpenAIRE |
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