Mutations at the Ribosomal S10 Gene in Clinical Strains of Staphylococcus aureus with Reduced Susceptibility to Tigecycline
| Autor: | Ariane Deplano, Sandrine Roisin, Magali Dodémont, Olivier Denis, Claire Nonhoff, M. Angeles Argudín |
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| Rok vydání: | 2018 |
| Předmět: |
Ribosomal Proteins
0301 basic medicine Staphylococcus aureus 030106 microbiology Mutant Microbial Sensitivity Tests Tigecycline Biology medicine.disease_cause Microbiology 03 medical and health sciences Bacterial Proteins Mechanisms of Resistance Drug Resistance Bacterial medicine Humans Pharmacology (medical) Gene Pharmacology Genetics chemistry.chemical_classification Strain (chemistry) Staphylococcal Infections Ribosomal RNA biology.organism_classification Anti-Bacterial Agents Amino acid Infectious Diseases Amino Acid Substitution chemistry Mutation Bacteria medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 62 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.01852-17 |
| Popis: | Mutations on the tip of the extended loop of the ribosomal S10 protein have been associated to tigecycline (TGC) resistance in passaged mutants of different bacteria species. This study described the first two clinical TGC-resistant Staphylococcus aureus isolates with these mutations. One strain (TGC MIC = 2 mg/liter) had a 12-nucleotide deletion affecting residues 56 to 59 (HKYK) of the S10 protein. The second strain (TGC MIC = 1 mg/liter) had amino acid substitutions (K57M and Y58F) previously described in S. aureus passaged mutants. |
| Databáze: | OpenAIRE |
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