The association of body size in early to mid-life with adult urinary 6-sulfatoxymelatonin levels among night shift health care workers
| Autor: | Eva S. Schernhammer, Cody Ramin, Jennifer Massa, Susan E. Hankinson, Elizabeth E. Devore, Susan B. Brown, Lani R. Wegrzyn, Jeffrey Pierre-Paul |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
medicine.medical_specialty Waist Birth weight Health Personnel Workload Body Mass Index Cohort Studies Young Adult Waist–hip ratio Internal medicine Work Schedule Tolerance Somatotype medicine Body Size Humans Young adult Morning Melatonin 2. Zero hunger business.industry Waist-Hip Ratio Height Weight change Public Health Environmental and Occupational Health Middle Aged 3. Good health Circadian Rhythm Endocrinology Creatinine aMT6s Cohort Female business Body mass index Demography Research Article |
| Zdroj: | BMC Public Health |
| ISSN: | 1471-2458 |
| Popis: | Background Adult body mass index (BMI) has been associated with urinary melatonin levels in humans; however, whether earlier-life body size is associated with melatonin, particularly among night shift workers, remains unknown. Methods We evaluated associations of birth weight, body shape (or somatotype) at ages 5 and 10, BMI at age 18 and adulthood, weight change since age 18, waist circumference, waist to hip ratio, and height with creatinine-adjusted morning urinary melatonin (6-sulfatoxymelatonin, aMT6s) levels among 1,343 healthy women (aged 32–53 at urine collection, 1996–1999) in the Nurses’ Health Study (NHS) II cohort. Using multivariable linear regression, we computed least-square mean aMT6s levels across categories of body size, and evaluated whether these associations were modified by night shift work. Results Adult BMI was inversely associated with aMT6s levels (mean aMT6s levels = 34 vs. 50 ng/mg creatinine, comparing adult BMI ≥30 vs. |
| Databáze: | OpenAIRE |
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