Prophylactic and Therapeutic Efficacy of Human Intravenous Immunoglobulin in Treating West Nile Virus Infection in Mice
| Autor: | D. Ben-Nathan, Shraga Segal, Shahar Robinzon, Bracha Rager-Zisman, Guy Tam, Shlomo Lustig |
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| Rok vydání: | 2003 |
| Předmět: |
Time Factors
viruses Population Virus Replication Immunoglobulin E Virus Mice Flaviviridae hemic and lymphatic diseases medicine Animals Humans Immunology and Allergy education Mice Inbred BALB C education.field_of_study Dose-Response Relationship Drug biology business.industry Immunization Passive Immunoglobulins Intravenous virus diseases medicine.disease biology.organism_classification Virology Disease Models Animal Flavivirus Infectious Diseases Immunology biology.protein Antibody business West Nile virus Meningitis West Nile Fever Encephalitis |
| Zdroj: | The Journal of Infectious Diseases. 188:5-12 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1086/376870 |
| Popis: | West Nile virus (WNV) is a mosquito-borne disease found most commonly in Africa, West Asia, and the Middle East, where up to 40% of the human population possesses antibodies. It is an emerging disease in the United States. Humans infected with WNV develop a febrile illness that can progress to meningitis or encephalitis. In mice, WNV causes central nervous system infection, paralysis, encephalitis, and death. Currently, no specific therapy or vaccine has been approved for human use. We examined the prophylactic and therapeutic efficacy of pooled human plasma (PP) and intravenous immunoglobulin (IVIG) for treatment of WNV-infected mice. Full protection was achieved when the infected mice were treated with pooled plasma or IVIG obtained from healthy Israeli blood donors that contained WNV-specific antibodies. Similar treatments using PP or IVIG obtained from US blood donors had no protective effect. Recovery of the lethally infected mice was dependent on the dose and time of IVIG administration. These results indicate that antibodies play a major role in protection and recovery from WNV infection and that IVIG can be used as first-line therapy. |
| Databáze: | OpenAIRE |
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