The role of extracellular DNA (exDNA) in cellular processes

Autor:	Enrique Pérez-Cárdenas, Ileana J Fernández-Domínguez, Catalina Trejo-Becerril, Joaquin Manzo-Merino, Alfonso Dueñas-González, Lucia Taja-Chayeb
Rok vydání:	2021
Předmět:	0301 basic medicine Pharmacology Cancer Research DNA Review Prognosis Extracellular dna Cell biology 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine Oncology chemistry Neoplasms 030220 oncology & carcinogenesis Humans Molecular Medicine
Zdroj:	Cancer Biol Ther
ISSN:	1555-8576 1538-4047
Popis:	Nowadays, extracellular DNA or circulating cell-free DNA is considered to be a molecule with clinical applications (diagnosis, prognosis, monitoring of treatment responses, or patient follow-up) in diverse pathologies, especially in cancer. Nevertheless, because of its molecular characteristics, it can have many other functions. This review focuses on the participation of extracellular DNA (exDNA) in fundamental processes such as cell signaling, coagulation, immunity, evolution through horizontal transfer of genetic information, and adaptive response to inflammatory processes. A deeper understanding of its role in each of these processes will allow development of better tools to monitor and control pathologies, as well as helping to generate new therapeutic options, beyond the applicability of DNA in liquid biopsy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b712c0580c3735963a2306816ef2491 https://doi.org/10.1080/15384047.2021.1890319 Zobrazit plný text záznamu