Tumor deposit is a poor prognostic indicator for patients who have stage II and III colorectal cancer with fewer than 4 lymph node metastases but not for those with 4 or more
| Autor: | Yasunobu Nishioka, Kinuko Nagayoshi, Tatsuya Manabe, Yusuke Mizuuchi, Minako Hirahashi, Takashi Ueki, Masao Tanaka, Yoshinao Oda |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty Multivariate analysis Colorectal cancer Stage ii Intra-Abdominal Fat Internal medicine medicine Humans Mesentery Neoplasm Invasiveness Stage (cooking) Lymph node Colectomy Aged Neoplasm Staging Retrospective Studies Aged 80 and over business.industry Gastroenterology Clinical course Rectum Cancer Retrospective cohort study General Medicine Middle Aged medicine.disease Prognosis Survival Analysis medicine.anatomical_structure Treatment Outcome Lymphatic Metastasis Multivariate Analysis Female business Colorectal Neoplasms Follow-Up Studies |
| Zdroj: | Diseases of the colon and rectum. 57(4) |
| ISSN: | 1530-0358 |
| Popis: | BACKGROUND Extranodal tumor deposits are involved in TNM classification. However, it is uncertain whether a tumor deposit is a regular lymph node metastasis, and its prognostic significance in patients with stage II or III colorectal cancer remains to be established. OBJECTIVE This study aimed to determine the prognostic significance of tumor deposits for stage II and III colorectal cancer. DESIGN This study is a retrospective review of clinicopathological data. SETTING This study was conducted at a tertiary care hospital/referral center in Japan. PATIENTS We reviewed the clinical course of 171 stage II and 173 stage III consecutive patients between January 1999 and December 2006. MAIN OUTCOME MEASURES We examined the clinicopathological features of colorectal cancers with tumor deposits and calculated overall survival and recurrence-free survival of the patients according to the status of tumor deposits. The primary outcome was the impact of tumor deposits on patient survival. RESULTS Thirty-five (10.2%) patients with colorectal cancers had tumor deposits in the pericolic and/or mesocolic region. Survival rates among the patients with tumor deposits were significantly lower than those without (5-year overall survival: 58.4% vs 81.0%, p < 0.0001; 5-year recurrence-free survival: 47.1% vs 73.4%, p < 0.0001). Tumor deposit was an independent prognostic factor for patients with colorectal cancer in multivariate analysis (overall survival: HR, 2.30; 95% CI, 1.26-4.04; p = 0.04; recurrence-free survival: HR, 2.42; 95% CI, 1.04-4.90; p = 0.04). Tumor deposit was an independent prognostic factor in N0 and N1 colorectal cancer, whereas N2 cancer had poor survival outcome regardless of tumor deposit. LIMITATIONS Our study was a single-institution retrospective study, and the numbers of patients were relatively small to draw firm conclusions. CONCLUSION Tumor deposit may be an independent adverse prognostic factor for stage II and III N1 colorectal cancer. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|