Reference range of random urinary calcium creatinine ratio in North Indian children and adolescents
| Autor: | Ambrish Mithal, Manchanda Raj Kumar, Nandita Gupta, Mahendra Kumar Garg, Raman K. Marwaha, Archna Narang, Aditi Chadha, Navin Dang |
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| Rok vydání: | 2018 |
| Předmět: |
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Children and adolescents Endocrinology Diabetes and Metabolism Physiology 030209 endocrinology & metabolism Reference range 03 medical and health sciences chemistry.chemical_compound Urinary calcium creatinine ratio 0302 clinical medicine 030225 pediatrics Vitamin D and neurology medicine Hypercalciuria Creatinine business.industry Weight category lcsh:RJ1-570 lcsh:Pediatrics medicine.disease Urinary calcium chemistry Pediatrics Perinatology and Child Health Secondary hyperparathyroidism Original Article business Body mass index |
| Zdroj: | Annals of Pediatric Endocrinology & Metabolism Annals of Pediatric Endocrinology & Metabolism, Vol 24, Iss 1, Pp 34-40 (2019) |
| ISSN: | 2287-1012 |
| Popis: | Purpose Urinary calcium creatinine ratio (UCaCrR) is a reliable indicator for monitoring hypercalciuria following vitamin D supplementation. However, the reference range varies from region to region. Previous studies did not take vitamin D and parathyroid hormone status into account while evaluating UCaCrR. Hence, we undertook this study to establish the 95th percentile of UCaCrR as an indicator of hypercalciuria in North Indian children and adolescents. Methods Four hundred seventy-three participants (boys 62.2%, girls 37.8%) with adequate dietary calcium intake, normal serum levels of 25-hydroxy-vitamin D (g20 ng/mL), and without secondary hyperparathyroidism following supplementation were selected for evaluation of UCaCrR. Results The mean age and body mass index of subjects were 11.2±2.6 years and 18.0±3.6 kg/m2, respectively. The 95th percentile of UCaCrR in the study population was 0.126. The mean, median, and 95th percentile of UCaCrR was significantly higher in prepubertal children (age ≤10 years) (0.0586±0.0374, median=0.0548, 95th percentile=0.136) compared to those g10 years old (0.0503±0.0363, median=0.0407, 95th percentile=0.123, P=0.02). No significant difference in UCaCrR was observed between genders and different weight categories. Conclusion UCaCrR of 0.13 defines the cutoff value for hypercalciuria in North Indian children and adolescents with adequate dietary intake of calcium and sufficient serum vitamin D levels. |
| Databáze: | OpenAIRE |
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