Limitations for TCR gene therapy by MHC-restricted fratricide and TCR-mediated hematopoietic stem cell toxicity
| Autor: | Bernhard Frankenberger, Dolores J. Schendel |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Genetic enhancement
Immunology chemical and pharmacologic phenomena survivin Major histocompatibility complex hyluronan-mediated motility receptor Antigen medicine Immunology and Allergy hematopoietic stem cell toxicity Receptor Author's View biology business.industry MHC-restricted fratricide T-cell receptor TCR gene therapy Hematopoietic stem cell Haematopoiesis medicine.anatomical_structure Oncology Cancer research biology.protein Stem cell business |
| Zdroj: | Oncoimmunology |
| ISSN: | 2162-402X 2162-4011 |
| Popis: | The clinical use of lymphocytes engineered to express high affinity T-cell receptors (TCRs) specific for two broadly expressed tumor-associated antigens is strongly limited by MHC-restricted fratricide of lymphocytes and TCR-mediated killing of hematopoietic stem cells. Specific clinical applications must therefore be conceived to bypass these limitations. |
| Databáze: | OpenAIRE |
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