Older Adults Who Maintained a Regular Physical Exercise Routine before the Pandemic Show Better Immune Response to Vaccination for COVID-19

Autor: Brenda Rodrigues Silva, Fernanda Rodrigues Monteiro, Kizzy Cezário, Jônatas Bussador do Amaral, Vitória Paixão, Ewin Barbosa Almeida, Carlos André Freitas dos Santos, Gislene Rocha Amirato, Danielle Bruna Leal Oliveira, Edison Luiz Durigon, Andressa Simões Aguiar, Rodolfo P. Vieira, Juliana de Melo Batista dos Santos, Guilherme Eustáquio Furtado, Carolina Nunes França, Marina Tiemi Shio, André Luis Lacerda Bachi
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: International Journal of Environmental Research and Public Health
Volume 20
Issue 3
Pages: 1939
ISSN: 1660-4601
DOI: 10.3390/ijerph20031939
Popis: Background: In this study, we aimed to investigate the specific-antibody response to the COVID-19 vaccination and the immunophenotyping of T cells in older adults who were engaged or not in an exercise training program before the pandemic. Methods: Ninety-three aged individuals (aged between 60 and 85 years) were separated into 3 groups: practitioners of physical exercise vaccinated with CoronaVac (PE-Co, n = 46), or vaccinated with ChadOx-1 (PE-Ch, n = 23), and non-practitioners vaccinated with ChadOx-1 (NPE-Ch, n = 24). Blood samples were collected before (pre) and 30 days after vaccination with the second vaccine dose. Results. Higher IgG levels and immunogenicity were found in the PE-Ch and NPE-Ch groups, whereas increased IgA levels were found only in the PE-Ch group post-vaccination. The PE-Co group showed a positive correlation between the IgA and IgG values, and lower IgG levels post-vaccination were associated with age. Significant alterations in the percentage of naive (CD28+CD57-), double-positive (CD28+CD57+), and senescent (CD28-CD57+) CD4+ T and CD8+ T cells were found post-vaccination, particularly in the PE-Ch group. Conclusions: The volunteers vaccinated with the ChadOx-1 presented not only a better antibody response but also a significant modulation in the percentage of T cell profiles, mainly in the previously exercised group.
Databáze: OpenAIRE
Externí odkaz: