Equine Glucose-6-phosphate Dehydrogenase Deficiency
| Autor: | D. A. Kinden, John W. Harvey, Steven L. Stockham |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
0301 basic medicine Hemolytic anemia Anemia Hemolytic medicine.medical_specialty Erythrocytes 040301 veterinary sciences Macrocytosis Glucosephosphate Dehydrogenase Biology 0403 veterinary science 03 medical and health sciences Internal medicine medicine Animals Horses Hyperbilirubinemia General Veterinary Pyknocytosis 04 agricultural and veterinary sciences medicine.disease Glucosephosphate Dehydrogenase Deficiency 030104 developmental biology Endocrinology Biochemistry Microscopy Electron Scanning Horse Diseases Congenital hemolytic anemia Pyruvate kinase Glucose-6-phosphate dehydrogenase deficiency Heinz body |
| Zdroj: | Veterinary Pathology. 31:518-527 |
| ISSN: | 1544-2217 0300-9858 |
| DOI: | 10.1177/030098589403100503 |
| Popis: | Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a well-characterized X-linked inherited disorder in humans but has not been reported in horses. We describe a persistent hemolytic anemia and hyperbilirubinemia due to a severe G6PD deficiency in an American Saddlebred colt. Other abnormalities in the colt's erythrocytes as compared with those of healthy horses ( n = 22–35) included increased activities of hexokinase and pyruvate kinase, decreased concentrations of reduced glutathione and reduced nicotinamide adenine dinucleotide phosphate (NADP), and increased concentration of oxidized NADP. Morphologic abnormalities included eccentrocytosis, pyknocytosis, anisocytosis, macrocytosis, and increased number of Howell-Jolly bodies. Scanning and transmission electron microscopic examinations revealed that eccentrocytes had contracted to spherical regions and thin collapsed regions. Eccentrocytes were more electron dense than were normal erythrocytes when examined by transmission electron microscopy. When exposed to acetylphenylhydrazine, erythrocytes from the G6PD-deficient colt produced more and smaller Heinz bodies than did erythrocytes from normal horses. Abnormalities in the colt's dam included presence of eccentrocytes and pyknocytes; her average erythrocyte G6PD activity was slightly below the range of reference values. |
| Databáze: | OpenAIRE |
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