Release of nerve growth factor by human pulmonary epithelial cells: role in airway inflammatory diseases
| Autor: | Hema J Patel, Alyson Fox, Peter J. Barnes, Maria G. Belvisi |
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| Rok vydání: | 2001 |
| Předmět: |
medicine.medical_specialty
Time Factors Necrosis medicine.medical_treatment Dexamethasone Epithelium Internal medicine Nerve Growth Factor Tumor Cells Cultured medicine Humans Lung Pharmacology A549 cell Dose-Response Relationship Drug medicine.diagnostic_test biology Tumor Necrosis Factor-alpha business.industry Growth factor Asthma respiratory tract diseases Endocrinology Bronchoalveolar lavage Nerve growth factor Cytokine biology.protein Respiratory epithelium medicine.symptom business Interleukin-1 Neurotrophin |
| Zdroj: | European Journal of Pharmacology. 424:159-162 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/s0014-2999(01)01138-4 |
| Popis: | Elevated levels of nerve growth factor (NGF) have been detected in the bronchoalveolar lavage fluid of patients with asthma. However, the source of this enhanced mediator production is not known. Here, we investigate the production of NGF from a human airway epithelial cell line (A549). Under basal conditions, A549 cells generated NGF in a time-dependent fashion. However, basal release was significantly augmented in a concentration-dependent manner in cells treated with interleukin-1beta (IL-1beta) or tumour necrosis factor-alpha (TNF-alpha) and inhibited by dexamethasone. These data suggest that NGF released from structural cells may be an important target for the anti-inflammatory effects of steroids in asthma therapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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