A case of primary lung squamous cell carcinoma mimicking malignant mesothelioma producing granulocyte colony stimulating factor with chemotherapy (cisplatin and gemcitabine)-associated thrombotic thrombocytopenic purpura (TTP); An autopsy case report
Autor: | Kenya Kanazawa, Takashi Umeda, Ryuichi Togawa, Julia Morimoto, Yuki Sato, Hiroyuki Minemura, Takaya Kawamata, Tatsuhiko Koizumi, Takefumi Nikaido, Natsumi Watanabe, Yoko Shibata, Hikaru Tomita, Atsuro Fukuhara, Mami Rikimaru, Kiyoshi Mori, Kenichiro Hirai, Yoshinori Tanino, Mikako Saito, Junpei Saito, Risa Kanai, Yasuhito Suzuki, Manabu Uematsu, Suguru Sato |
---|---|
Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Pulmonary and Respiratory Medicine Oncology Male Mesothelioma Cancer Research medicine.medical_specialty Thrombotic microangiopathy Lung Neoplasms medicine.medical_treatment Thrombotic thrombocytopenic purpura 03 medical and health sciences 0302 clinical medicine hemic and lymphatic diseases Internal medicine Antineoplastic Combined Chemotherapy Protocols Granulocyte Colony-Stimulating Factor medicine Carcinoma Humans Aged Cisplatin Chemotherapy Purpura Thrombotic Thrombocytopenic business.industry Mesothelioma Malignant respiratory system Acute Kidney Injury medicine.disease Gemcitabine Granulocyte colony-stimulating factor 030104 developmental biology 030220 oncology & carcinogenesis Positron-Emission Tomography Carcinoma Squamous Cell Autopsy business Tomography X-Ray Computed medicine.drug |
Zdroj: | Lung cancer (Amsterdam, Netherlands). 136 |
ISSN: | 1872-8332 |
Popis: | Objectives Thrombotic thrombocytopenic purpura (TTP) is a rare form of thrombotic microangiopathy. In recent years, an extensive variety of drugs, including certain cytotoxic agents, have been reported to be associated with TTP. Additionally, several studies have reported that granulocyte colony-stimulating factor (G-CSF) was produced by lung carcinoma. G-CSF-producing carcinoma also produces various other cytokines, which may cause vascular endothelial damage and trigger TTP development. However, there has been no report describing G-CSF-producing carcinoma combined with TTP. We report a rare case of pseudomesothliomatous squamous cell lung carcinoma producing G-CSF along with chemotherapy associated TTP. Materials and Methods A 66-year-old man with pseudomesotheliomatous primary squamous cell lung carcinoma was treated with chemotherapy consisting of cisplatin and gemcitabine as the first line treatment. However, thrombocytopenia, acute renal dysfunction and acute respiratory failure occurred after starting the first chemotherapy cycle. As a result, the patient died, and an autopsy was performed. Results According to the autopsy findings, a diagnosis of primary lung squamous cell carcinoma producing G-CSF associated with TTP was made. Conclusion Chemotherapy-related TTP should be considered when anemia and thrombocytopenia progress rapidly in patients who are under chemotherapy treatment. Furthermore, the current case may provide a possible link between TTP and G-CSF-producing tumor. |
Databáze: | OpenAIRE |
Externí odkaz: |