A case of primary lung squamous cell carcinoma mimicking malignant mesothelioma producing granulocyte colony stimulating factor with chemotherapy (cisplatin and gemcitabine)-associated thrombotic thrombocytopenic purpura (TTP); An autopsy case report

Autor: Kenya Kanazawa, Takashi Umeda, Ryuichi Togawa, Julia Morimoto, Yuki Sato, Hiroyuki Minemura, Takaya Kawamata, Tatsuhiko Koizumi, Takefumi Nikaido, Natsumi Watanabe, Yoko Shibata, Hikaru Tomita, Atsuro Fukuhara, Mami Rikimaru, Kiyoshi Mori, Kenichiro Hirai, Yoshinori Tanino, Mikako Saito, Junpei Saito, Risa Kanai, Yasuhito Suzuki, Manabu Uematsu, Suguru Sato
Rok vydání: 2019
Předmět:
0301 basic medicine
Pulmonary and Respiratory Medicine
Oncology
Male
Mesothelioma
Cancer Research
medicine.medical_specialty
Thrombotic microangiopathy
Lung Neoplasms
medicine.medical_treatment
Thrombotic thrombocytopenic purpura
03 medical and health sciences
0302 clinical medicine
hemic and lymphatic diseases
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
Granulocyte Colony-Stimulating Factor
medicine
Carcinoma
Humans
Aged
Cisplatin
Chemotherapy
Purpura
Thrombotic Thrombocytopenic
business.industry
Mesothelioma
Malignant
respiratory system
Acute Kidney Injury
medicine.disease
Gemcitabine
Granulocyte colony-stimulating factor
030104 developmental biology
030220 oncology & carcinogenesis
Positron-Emission Tomography
Carcinoma
Squamous Cell
Autopsy
business
Tomography
X-Ray Computed
medicine.drug
Zdroj: Lung cancer (Amsterdam, Netherlands). 136
ISSN: 1872-8332
Popis: Objectives Thrombotic thrombocytopenic purpura (TTP) is a rare form of thrombotic microangiopathy. In recent years, an extensive variety of drugs, including certain cytotoxic agents, have been reported to be associated with TTP. Additionally, several studies have reported that granulocyte colony-stimulating factor (G-CSF) was produced by lung carcinoma. G-CSF-producing carcinoma also produces various other cytokines, which may cause vascular endothelial damage and trigger TTP development. However, there has been no report describing G-CSF-producing carcinoma combined with TTP. We report a rare case of pseudomesothliomatous squamous cell lung carcinoma producing G-CSF along with chemotherapy associated TTP. Materials and Methods A 66-year-old man with pseudomesotheliomatous primary squamous cell lung carcinoma was treated with chemotherapy consisting of cisplatin and gemcitabine as the first line treatment. However, thrombocytopenia, acute renal dysfunction and acute respiratory failure occurred after starting the first chemotherapy cycle. As a result, the patient died, and an autopsy was performed. Results According to the autopsy findings, a diagnosis of primary lung squamous cell carcinoma producing G-CSF associated with TTP was made. Conclusion Chemotherapy-related TTP should be considered when anemia and thrombocytopenia progress rapidly in patients who are under chemotherapy treatment. Furthermore, the current case may provide a possible link between TTP and G-CSF-producing tumor.
Databáze: OpenAIRE
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