Nephron deficit is not required for progressive proteinuria development in the Munich Wistar Frömter rat
| Autor: | Maria Schlesener, Norbert Wendt, Matthias Huber, Kristina Kuhn, Reinhold Kreutz, Peter Kossmehl, Jens R. Nyengaard, Angela Schulz, Jonna Hänsch |
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| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Physiology Nephron Biology urologic and male genital diseases Animals Congenic Rats Inbred SHR Internal medicine Genetic model Genetics medicine Albuminuria Animals Sex Characteristics Kidney Proteinuria urogenital system Nephrons Chromosomes Mammalian Rats medicine.anatomical_structure Endocrinology Hypertension Female medicine.symptom |
| Zdroj: | Schulz, A, Hänsch, J, Kuhn, K, Schlesener, M, Kossmehl, P, Nyengaard, J R, Wendt, N, Huber, M & Kreutz, R 2008, ' Nephron deficit is not required for progressive proteinuria development in the Munich Wistar Frömter rat ', Physiological Genomics, vol. 35, no. 1, pp. 30-5 . https://doi.org/10.1152/physiolgenomics.90270.2008 |
| ISSN: | 1531-2267 1094-8341 |
| Popis: | The Munich Wistar Frömter (MWF) rat represents a genetic model with an inherited nephron deficit and exhibits mild hypertension and progressive albuminuria, which is more pronounced in males than females. Previously, we demonstrated in a consomic strain that replacement of a quantitative trait locus on chromosome 6 normalized the nephron deficit and suppressed albuminuria development, suggesting a link between the two findings. Here we tested the role of a second major locus linked to albuminuria in MWF on chromosome 8 and generated the consomic strain MWF-8SHRby transfer of chromosome 8 from spontaneously hypertensive rats (SHR) into MWF. The early onset of albuminuria at 8 wk of age in MWF (>50-fold increase compared with SHR) was significantly suppressed in consomic animals, and the development of marked proteinuria at 32 wk significantly diminished. Total nephron number in consomic rats (23,771 ± 1,352) and MWF (27,028 ± 1,322) were similar and significantly lower (−36%) compared with SHR (36,979 ± 1,352, P < 0.0001). The development of mild albuminuria in female MWF was also significantly diminished in MWF-8SHR. Thus, the development of overt and mild albuminuria in male and female MWF rats is not a mandatory consequence of the inherited nephron deficit. The locus on chromosome 8 appears of interest, because its exchange between MWF and SHR protects against the development of albuminuria in MWF-8SHRanimals despite their inherited nephron deficit and higher systolic blood pressure. |
| Databáze: | OpenAIRE |
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