Synthesis and blood glucose lowering activity of some novel benzenesulfonylthiourea derivatives substituted with 4-aryl-1-oxophthalazin-2(1H)yl-ones
| Autor: | Mohammed Samim, Rafia Bashir, Kalim Javed, Shafiya Yaseen, Pooja Rathore, Syed Ovais |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Blood Glucose
Male Stereochemistry Rat model Medicinal chemistry Structure-Activity Relationship chemistry.chemical_compound Isothiocyanates Drug Discovery Acetone Animals Hypoglycemic Agents Rats Wistar Pharmacology Glucose lowering Aryl Benzenesulfonates Thiourea General Medicine Rats Glucose chemistry Elemental analysis Drug Design Hyperglycemia Isothiocyanate Anhydrous Proton NMR Phthalazines Female |
| Zdroj: | Journal of Enzyme Inhibition and Medicinal Chemistry. 29:362-366 |
| ISSN: | 1475-6374 1475-6366 |
| Popis: | Some new benzenesulfonylthiourea derivatives substituted with phthalazones (2a–q) were synthesized by refluxing the appropriate 4-aryl-1-oxophthalazin-2(1H)yl benzenesulfonamides with isothiocyanate in dry acetone over anhydrous K2CO3. All the synthesized compounds were characterized on the basis of IR, 1H NMR, MS data and elemental analysis. These synthesized compounds (2a–q) at the dose of 20 mg/kg were tested for antihyperglycemic activity in the glucose-fed hyperglycemic normal rat model and among these compounds 2f and 2m showed modest antihyperglycemic activity. |
| Databáze: | OpenAIRE |
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