Epoxide hydratase and glutathione S-transferase activities in human lungs
Autor: | Frank E. Greene, Bengt Jernström |
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Rok vydání: | 1980 |
Předmět: |
Epoxide Hydrolases
chemistry.chemical_classification Cancer Research Lung Neoplasms Cytochrome biology Metabolism Glutathione respiratory system Monooxygenase medicine.disease chemistry.chemical_compound Glutathione S-transferase Enzyme Oncology Biochemistry chemistry medicine biology.protein Humans Benzopyrenes Lung cancer Lung Carcinogen Glutathione Transferase |
Zdroj: | Cancer Letters. 8:235-239 |
ISSN: | 0304-3835 |
DOI: | 10.1016/0304-3835(80)90008-7 |
Popis: | It has been reported human lung has cytochrome P-450 dependent mono-oxygenase activity which is necessary for the formation of mutagneic and carcinogenic metabolities of polycyclic aromatic hydrocarbons, such as benzo[a]pyrene. We now report epoxide hydratase and glutathione S-transferase, enzymes important in the further metabolism of certain benzo[a]-pyrene metabolites formed by the monooxygenase system, have been detected in human lung tissues from patients undergoing surgery for lung cancer. |
Databáze: | OpenAIRE |
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