Epoxide hydratase and glutathione S-transferase activities in human lungs

Autor: Frank E. Greene, Bengt Jernström
Rok vydání: 1980
Předmět:
Zdroj: Cancer Letters. 8:235-239
ISSN: 0304-3835
DOI: 10.1016/0304-3835(80)90008-7
Popis: It has been reported human lung has cytochrome P-450 dependent mono-oxygenase activity which is necessary for the formation of mutagneic and carcinogenic metabolities of polycyclic aromatic hydrocarbons, such as benzo[a]pyrene. We now report epoxide hydratase and glutathione S-transferase, enzymes important in the further metabolism of certain benzo[a]-pyrene metabolites formed by the monooxygenase system, have been detected in human lung tissues from patients undergoing surgery for lung cancer.
Databáze: OpenAIRE