Pharmacokinetics of transdermal fentanyl in the peri-operative period in young children
| Autor: | O. Paut, J. Camboulives, J. C. Levron, L. Viard, J. P. Lemoing |
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| Rok vydání: | 2000 |
| Předmět: |
Administration
Cutaneous Body weight law.invention Fentanyl Pharmacokinetics law Humans Medicine Transdermal Intraoperative Care business.industry Body Weight Age Factors Area under the curve Infant Half-life Perioperative Intensive care unit Analgesics Opioid Anesthesiology and Pain Medicine Area Under Curve Child Preschool Anesthesia business Half-Life medicine.drug |
| Zdroj: | Anaesthesia. 55:1202-1207 |
| ISSN: | 0003-2409 |
| DOI: | 10.1046/j.1365-2044.2000.01615-3.x |
| Popis: | The pharmacokinetics of transdermal fentanyl were assessed in eight children aged 18-60 months, weighing 11-20 kg and monitored postoperatively in the intensive care unit. A patch, delivering 25 microg.h-1 of fentanyl, was applied for 72 h from the induction of anaesthesia. Plasma fentanyl concentrations were measured over 144 h. Mean (SD) peak concentration of fentanyl was 1.7 (0.66) ng.ml-1 and time to reach maximal plasma concentration was 18 (11) h. The elimination half-life was 14.5 (6.2) h, and the area under the curve for plasma fentanyl concentration (0-144 h) was 86.8 (27) ng.h.ml-1. Maximal fentanyl concentration was negatively correlated with patient age (r = - 0.71; p = 0.049) but not with body weight. These results suggest that the pharmacokinetics of transdermal fentanyl in children are similar to those in adults. |
| Databáze: | OpenAIRE |
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