Inhibitory properties of the antibody response to Plasmodium vivax Duffy binding protein in an area with unstable malaria transmission
Autor: | Flávia A. Souza-Silva, John H. Adams, Isabela P. Ceravolo, C. F. A. Brito, Antoniana U. Krettli, Luzia H. Carvalho, Cor Jesus Fernandes Fontes, A. P. Madureira, Érika Martins Braga, José Maria de Souza |
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Rok vydání: | 2008 |
Předmět: |
Erythrocytes
genetic structures Immunology Population Plasmodium vivax Protozoan Proteins Antibodies Protozoan Antigens Protozoan Enzyme-Linked Immunosorbent Assay Receptors Cell Surface Transfection Pathogenesis Antigen parasitic diseases medicine Malaria Vivax Animals Humans cardiovascular diseases education education.field_of_study Microscopy Confocal Polymorphism Genetic biology Malaria vaccine Binding protein General Medicine biology.organism_classification medicine.disease Virology biology.protein Antibody Malaria Brazil circulatory and respiratory physiology |
Zdroj: | Scandinavian journal of immunology. 67(3) |
ISSN: | 1365-3083 |
Popis: | The function of the Plasmodium vivax Duffy binding protein (DBP) during the erythrocyte invasion process is critical for successful parasite growth and pathogenesis in human infections. Although DBP is the subject of intensive malaria vaccine research, investigations on the functional proprieties of anti-DBP antibodies in the human population have been limited [Infect Immun68 (2000) 3164]. In the present study, we examined the ability of sera from different populations of the Brazilian Amazon--an area of markedly unstable malaria transmission--to inhibit the erythrocyte-binding function of the DBP ligand domain (region II, DBP(II)). We found that long-term exposure to malaria in the Amazon area elicits DBP-specific antibodies that inhibit the binding of different DBP(II) variants to erythrocytes. Despite the great variability of inhibitory antibody responses observed among study participants, we observed a positive correlation between erythrocyte binding-inhibitory activity and enzyme-linked immunosorbent assay anti-DBP antibodies. Of importance, there was a non-significant tendency towards increased levels of anti-DBP antibodies among individuals with asymptomatic P. vivax infections. |
Databáze: | OpenAIRE |
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