Post-transplant diabetes mellitus in pediatric liver transplantation
| Autor: | Eba Hathout, Essam Imseis, Joyce K. Johnston, Estella M. Alonso, Karen Martz, Suzanne V. McDiarmid, Richard E. Chinnock, James Lopez, Ravinder Anand |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Adolescent medicine.medical_treatment Cytomegalovirus Liver transplantation Tacrolimus Body Mass Index Islets of Langerhans Internal medicine Diabetes mellitus Diabetes Mellitus medicine Humans Child Transplantation business.industry Incidence (epidemiology) Infant Newborn Infant Immunosuppression medicine.disease Liver Transplantation Surgery surgical procedures operative El Niño Child Preschool Multivariate Analysis Pediatrics Perinatology and Child Health Female business Body mass index Immunosuppressive Agents |
| Zdroj: | Pediatric Transplantation. 13:599-605 |
| ISSN: | 1399-3046 1397-3142 |
| DOI: | 10.1111/j.1399-3046.2007.00603.x |
| Popis: | To determine the characteristics of pediatric liver transplant recipients who develop GI and/or PTDM, data on children undergoing their first liver transplant from the SPLIT database were analyzed (n = 1611). Recipient and donor characteristics that were evaluated included age at transplant, gender, race, primary disease, hospitalization status at transplant, BMI, recipient and donor CMV status, donor type, donor age, and primary immunosuppression. GI/PTDM was found in 214 individuals (13%) of whom 166 (78%) were diagnosed within 30 days of transplantation (early GI/PTDM). Multivariate analyses suggests that age >5 yr at transplant, hospitalization at transplant, a primary diagnosis other than BA, early steroid use, and tacrolimus use are associated with increased incidence of early GI. Routine monitoring for the development of GI and post-transplant diabetes is indicated in the short- and long-term care of children after liver transplantation. |
| Databáze: | OpenAIRE |
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